Monocarboxylate transporter 6

SLC16A5
Identifiers
Aliases	SLC16A5, MCT5, MCT6, solute carrier family 16 member 5, Monocarboxylate transporter 6
External IDs	OMIM: 603879; MGI: 2443515; HomoloGene: 20985; GeneCards: SLC16A5; OMA:SLC16A5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,087,727 bp[1] End 75,106,162 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,353,300 bp[2] End 115,365,224 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of transverse colon right uterine tube pancreatic ductal cell upper lobe of left lung oocyte duodenum right lung epithelium of nasopharynx monocyte Top expressed in thymus jejunum right kidney duodenum epithelium of stomach colon left colon embryo human kidney ileum More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity monocarboxylic acid transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process monocarboxylic acid transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9121 217316 Ensembl ENSG00000170190 ENSMUSG00000045775 UniProt O15375 G5E8K6 RefSeq (mRNA) NM_001271765 NM_004695 NM_001369668 NM_001080934 NM_001359606 NM_001359608 NM_001359609 RefSeq (protein) NP_001258694 NP_004686 NP_001356597 NP_001074403 NP_001346535 NP_001346537 NP_001346538 Location (UCSC) Chr 17: 75.09 – 75.11 Mb Chr 11: 115.35 – 115.37 Mb PubMed search [3] [4]
Wikidata
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Monocarboxylate transporter 6 (MCT6) is a protein in humans that is encoded by the SLC16A5 gene.^[5]

This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].