NAPG

Protein-coding gene in the species Homo sapiens
NAPG
Identifiers
AliasesNAPG, GAMMASNAP, NSF attachment protein gamma
External IDsOMIM: 603216; MGI: 104561; HomoloGene: 2838; GeneCards: NAPG; OMA:NAPG - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for NAPG
Genomic location for NAPG
Band18p11.22Start10,525,905 bp[1]
End10,552,764 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for NAPG
Genomic location for NAPG
Band18|18 E1Start63,110,902 bp[2]
End63,132,521 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • pons

  • Pars compacta

  • Brodmann area 23

  • islet of Langerhans

  • C1 segment

  • lateral nuclear group of thalamus

  • middle temporal gyrus

  • dorsolateral prefrontal cortex

  • Brodmann area 9
Top expressed in
  • subiculum

  • pontine nuclei

  • piriform cortex

  • central gray substance of midbrain

  • medial dorsal nucleus

  • primary motor cortex

  • inferior colliculus

  • subdivision of hippocampus

  • Region I of hippocampus proper

  • habenula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • syntaxin binding
  • protein binding
  • soluble NSF attachment protein activity
Cellular component
  • myelin sheath
  • lysosomal membrane
  • SNARE complex
  • extracellular exosome
  • membrane
  • mitochondrion
  • vacuolar membrane
  • synapse
Biological process
  • protein transport
  • protein stabilization
  • membrane fusion
  • intracellular protein transport
  • intra-Golgi vesicle-mediated transport
  • vesicle-mediated transport
  • transport
  • protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8774

108123

Ensembl

ENSG00000134265

ENSMUSG00000024581

UniProt

Q99747

Q9CWZ7

RefSeq (mRNA)

NM_003826

NM_028017

RefSeq (protein)

NP_003817

NP_082293

Location (UCSC)Chr 18: 10.53 – 10.55 MbChr 18: 63.11 – 63.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-soluble NSF attachment protein is a SNAP protein that in humans is encoded by the NAPG gene.[5][6]

Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134265 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024581 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW (Sep 1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery". Blood. 90 (4): 1490–500. doi:10.1182/blood.V90.4.1490. PMID 9269766.
  6. ^ a b "Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma".

Further reading

  • Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion". J. Cell Biol. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316.
  • Whiteheart SW, Brunner M, Wilson DW, et al. (1992). "Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes". J. Biol. Chem. 267 (17): 12239–43. doi:10.1016/S0021-9258(19)49830-X. PMID 1601890.
  • Whiteheart SW, Griff IC, Brunner M, et al. (1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform". Nature. 362 (6418): 353–5. Bibcode:1993Natur.362..353W. doi:10.1038/362353a0. PMID 8455721. S2CID 4341471.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Mastick CC, Falick AL (1997). "Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes". Endocrinology. 138 (6): 2391–7. doi:10.1210/endo.138.6.5166. PMID 9165027.
  • Subramaniam VN, Loh E, Horstmann H, et al. (2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). J. Cell Sci. 113 (6): 997–1008. doi:10.1242/jcs.113.6.997. PMID 10683148.
  • Chen D, Xu W, He P, et al. (2001). "Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria". J. Biol. Chem. 276 (16): 13127–35. doi:10.1074/jbc.M009424200. PMID 11278501.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP". J. Biol. Chem. 278 (15): 13531–8. doi:10.1074/jbc.M213205200. PMID 12554740.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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