NECAB2

Protein-coding gene in the species Homo sapiens
NECAB2
Identifiers
AliasesNECAB2, EFCBP2, N-terminal EF-hand calcium binding protein 2, stip-2
External IDsOMIM: 618130; MGI: 2152211; HomoloGene: 62200; GeneCards: NECAB2; OMA:NECAB2 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for NECAB2
Genomic location for NECAB2
Band16q23.3Start83,968,244 bp[1]
End84,002,776 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NECAB2
Genomic location for NECAB2
Band8|8 E1Start120,173,458 bp[2]
End120,199,379 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nucleus accumbens

  • caudate nucleus

  • amygdala

  • putamen

  • cingulate gyrus

  • anterior cingulate cortex

  • right frontal lobe

  • Brodmann area 9

  • hypothalamus

  • prefrontal cortex
Top expressed in
  • habenula

  • olfactory tubercle

  • lateral septal nucleus

  • dentate gyrus of hippocampal formation granule cell

  • medial geniculate nucleus

  • anterior amygdaloid area

  • medial dorsal nucleus

  • subiculum

  • nucleus accumbens

  • globus pallidus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • protein binding
  • calcium ion binding
  • A2A adenosine receptor binding
  • type 5 metabotropic glutamate receptor binding
  • identical protein binding
Cellular component
  • cytoplasm
  • plasma membrane
  • membrane
  • axon
  • dendrite
  • cell projection
Biological process
  • positive regulation of adenosine receptor signaling pathway
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of glutamate receptor signaling pathway
  • negative regulation of G protein-coupled receptor internalization
  • positive regulation of protein localization to membrane
  • regulation of amyloid precursor protein biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54550

117148

Ensembl

ENSG00000103154

ENSMUSG00000031837

UniProt

Q7Z6G3

Q91ZP9

RefSeq (mRNA)

NM_019065
NM_001329748
NM_001329749

NM_054095

RefSeq (protein)

NP_001316677
NP_001316678
NP_061938

NP_473436

Location (UCSC)Chr 16: 83.97 – 84 MbChr 8: 120.17 – 120.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103154 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031837 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sugita S, Ho A, Sudhof TC (Jun 2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience. 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471. S2CID 18740496.
  6. ^ "Entrez Gene: EFCBP2 EF-hand calcium binding protein 2".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Bernier G, Vukovich W, Neidhardt L, et al. (2001). "Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium". Development. 128 (20): 3987–94. doi:10.1242/dev.128.20.3987. PMID 11641222.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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