NETO1

Protein-coding gene in the species Homo sapiens
NETO1
Identifiers
AliasesNETO1, BCTL1, BTCL1, neuropilin and tolloid like 1
External IDsOMIM: 607973; MGI: 2180216; HomoloGene: 16367; GeneCards: NETO1; OMA:NETO1 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for NETO1
Genomic location for NETO1
Band18q22.3Start72,742,314 bp[1]
End72,868,146 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for NETO1
Genomic location for NETO1
Band18|18 E4Start86,394,952 bp[2]
End86,506,718 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • Brodmann area 9

  • cingulate gyrus

  • anterior cingulate cortex

  • caudate nucleus

  • putamen

  • nucleus accumbens

  • right frontal lobe

  • testicle

  • amygdala
Top expressed in
  • dorsal striatum

  • dentate gyrus of hippocampal formation granule cell

  • nucleus accumbens

  • subiculum

  • olfactory tubercle

  • hippocampus proper

  • superior frontal gyrus

  • amygdala

  • visual cortex

  • primary visual cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ionotropic glutamate receptor binding
Cellular component
  • integral component of membrane
  • extracellular region
  • cell junction
  • postsynaptic membrane
  • plasma membrane
  • synapse
  • excitatory synapse
  • membrane
  • postsynaptic density
  • postsynaptic density membrane
  • glutamatergic synapse
  • integral component of postsynaptic density membrane
Biological process
  • visual learning
  • regulation of neuronal synaptic plasticity
  • receptor localization to synapse
  • regulation of long-term neuronal synaptic plasticity
  • memory
  • positive regulation of excitatory postsynaptic potential
  • regulation of kainate selective glutamate receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81832

246317

Ensembl

ENSG00000166342

ENSMUSG00000050321

UniProt

Q8TDF5

Q8R4I7

RefSeq (mRNA)
NM_001201465
NM_138966
NM_138999
NM_153181
NM_001354017

NM_001354018
NM_001354020
NM_001354021
NM_001354022

NM_144946
NM_001360910

RefSeq (protein)
NP_001188394
NP_620416
NP_620552
NP_001340946
NP_001340947

NP_001340949
NP_001340950
NP_001340951

NP_659195
NP_001347839

Location (UCSC)Chr 18: 72.74 – 72.87 MbChr 18: 86.39 – 86.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropilin (NRP) and tolloid (TLL)-like 1 is a protein that in humans is encoded by the NETO1 gene.[5]

Function

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166342 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050321 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Neuropilin (NRP) and tolloid (TLL)-like 1".

Further reading

  • Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR (February 2009). "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning". PLOS Biology. 7 (2): e41. doi:10.1371/journal.pbio.1000041. PMC 2652390. PMID 19243221.
  • Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N (2011). "A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population". PLOS ONE. 6 (12): e28929. Bibcode:2011PLoSO...628929B. doi:10.1371/journal.pone.0028929. PMC 3243668. PMID 22205981.
  • Stöhr H, Berger C, Fröhlich S, Weber BH (March 2002). "A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain". Gene. 286 (2): 223–31. doi:10.1016/s0378-1119(02)00438-9. PMID 11943477.
  • Benjamin DJ, Cesarini D, van der Loos MJ, Dawes CT, Koellinger PD, Magnusson PK, Chabris CF, Conley D, Laibson D, Johannesson M, Visscher PM (May 2012). "The genetic architecture of economic and political preferences" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 109 (21): 8026–31. Bibcode:2012PNAS..109.8026B. doi:10.1073/pnas.1120666109. PMC 3361436. PMID 22566634.
  • O'Donnell L, Soileau B, Heard P, Carter E, Sebold C, Gelfond J, Hale DE, Cody JD (August 2010). "Genetic determinants of autism in individuals with deletions of 18q". Human Genetics. 128 (2): 155–64. doi:10.1007/s00439-010-0839-y. PMID 20499253. S2CID 23659069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e