NMD3

Protein-coding gene in the species Homo sapiens
NMD3
Identifiers
AliasesNMD3, CGI-07, NMD3 ribosome export adaptor
External IDsOMIM: 611021; MGI: 2140103; HomoloGene: 6127; GeneCards: NMD3; OMA:NMD3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for NMD3
Genomic location for NMD3
Band3q26.1Start161,104,696 bp[1]
End161,253,532 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for NMD3
Genomic location for NMD3
Band3|3 E1- E2Start69,629,318 bp[2]
End69,663,706 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • germinal epithelium

  • skin of thigh

  • skin of hip

  • parotid gland

  • secondary oocyte

  • amniotic fluid

  • parietal pleura

  • visceral pleura

  • gingival epithelium
Top expressed in
  • embryo

  • secondary oocyte

  • embryo

  • epiblast

  • primary oocyte

  • primitive streak

  • zygote

  • tail of embryo

  • morula

  • Paneth cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein-macromolecule adaptor activity
  • RNA binding
  • ribosomal large subunit binding
Cellular component
  • nucleus
  • membrane
  • nucleolus
  • cytoplasm
  • nucleoplasm
Biological process
  • protein transport
  • ribosomal large subunit export from nucleus
  • positive regulation of RNA biosynthetic process
  • positive regulation of protein localization to nucleolus
  • positive regulation of protein binding
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51068

97112

Ensembl

ENSG00000169251

ENSMUSG00000027787

UniProt

Q96D46

Q99L48

RefSeq (mRNA)

NM_015938
NM_001320227

NM_133787

RefSeq (protein)

NP_001307156
NP_057022

NP_598548

Location (UCSC)Chr 3: 161.1 – 161.25 MbChr 3: 69.63 – 69.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal export protein NMD3 is a protein that in humans is encoded by the NMD3 gene.[5][6][7]

Interactions

NMD3 has been shown to interact with XPO1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169251 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027787 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. ^ Trotta CR, Lund E, Kahan L, Johnson AW, Dahlberg JE (May 2003). "Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates". EMBO J. 22 (11): 2841–51. doi:10.1093/emboj/cdg249. PMC 156746. PMID 12773398.
  7. ^ "Entrez Gene: NMD3 NMD3 homolog (S. cerevisiae)".
  8. ^ Thomas F, Kutay U (Jun 2003). "Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway". J. Cell Sci. 116 (Pt 12): 2409–19. doi:10.1242/jcs.00464. PMID 12724356.

Further reading

  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Thomas F, Kutay U (2003). "Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway". J. Cell Sci. 116 (Pt 12): 2409–19. doi:10.1242/jcs.00464. PMID 12724356.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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