NPLOC4

Protein-coding gene in humans
NPLOC4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2PJH

Identifiers
AliasesNPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor
External IDsOMIM: 606590; MGI: 2679787; HomoloGene: 5403; GeneCards: NPLOC4; OMA:NPLOC4 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NPLOC4
Genomic location for NPLOC4
Band17q25.3Start81,556,887 bp[1]
End81,648,465 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for NPLOC4
Genomic location for NPLOC4
Band11|11 E2Start120,271,196 bp[2]
End120,328,534 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • apex of heart

  • muscle of thigh

  • stromal cell of endometrium

  • right testis

  • right coronary artery

  • islet of Langerhans

  • left testis

  • left ventricle

  • right adrenal gland
Top expressed in
  • spermatocyte

  • muscle of thigh

  • cumulus cell

  • interventricular septum

  • ascending aorta

  • aortic valve

  • spermatid

  • supraoptic nucleus

  • seminiferous tubule

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ubiquitin binding
  • protein binding
  • metal ion binding
  • ubiquitin protein ligase binding
Cellular component
  • cytoplasm
  • cytosol
  • nuclear outer membrane-endoplasmic reticulum membrane network
  • endoplasmic reticulum
  • nucleus
  • UFD1-NPL4 complex
  • nucleoplasm
  • VCP-NPL4-UFD1 AAA ATPase complex
Biological process
  • error-free translesion synthesis
  • retrograde protein transport, ER to cytosol
  • Golgi organization
  • ubiquitin-dependent ERAD pathway
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • negative regulation of type I interferon production
  • negative regulation of RIG-I signaling pathway
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55666

217365

Ensembl

ENSG00000182446

ENSMUSG00000039703

UniProt

Q8TAT6

P60670

RefSeq (mRNA)

NM_017921
NM_001369698

NM_001195023
NM_199469

RefSeq (protein)

NP_060391
NP_001356627
NP_060391.2

NP_001181952
NP_955763

Location (UCSC)Chr 17: 81.56 – 81.65 MbChr 11: 120.27 – 120.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.[5][6][7]

Interactions

NPLOC4 has been shown to interact with UFD1L.[5][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182446 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039703 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (Sep 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
  6. ^ Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G (Jun 2000). "A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways". EMBO J. 19 (10): 2181–92. doi:10.1093/emboj/19.10.2181. PMC 384367. PMID 10811609.
  7. ^ "Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)".
  8. ^ Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (Aug 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

Further reading

  • McConnell E, Lass A, Wójcik C (2007). "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation". Biochem. Biophys. Res. Commun. 355 (4): 1087–90. doi:10.1016/j.bbrc.2007.02.077. PMID 17331469.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • v
  • t
  • e
  • 1nj3: Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4
    1nj3: Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4
  • 1q5w: Ubiquitin Recognition by Npl4 Zinc-Fingers
    1q5w: Ubiquitin Recognition by Npl4 Zinc-Fingers
  • 2pjh: Structural Model of the p97 N domain- npl4 UBD complex
    2pjh: Structural Model of the p97 N domain- npl4 UBD complex


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