NPLOC4 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/2/26/Protein_NPLOC4_PDB_1nj3.png/250px-Protein_NPLOC4_PDB_1nj3.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | NPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor |
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External IDs | OMIM: 606590; MGI: 2679787; HomoloGene: 5403; GeneCards: NPLOC4; OMA:NPLOC4 - orthologs |
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Gene location (Human) |
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![Chromosome 17 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png) | Chr. | Chromosome 17 (human)[1] |
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| Band | 17q25.3 | Start | 81,556,887 bp[1] |
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End | 81,648,465 bp[1] |
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Gene location (Mouse) |
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![Chromosome 11 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 E2 | Start | 120,271,196 bp[2] |
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End | 120,328,534 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gastrocnemius muscle
- apex of heart
- muscle of thigh
- stromal cell of endometrium
- right testis
- right coronary artery
- islet of Langerhans
- left testis
- left ventricle
- right adrenal gland
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| Top expressed in | - spermatocyte
- muscle of thigh
- cumulus cell
- interventricular septum
- ascending aorta
- aortic valve
- spermatid
- supraoptic nucleus
- seminiferous tubule
- lip
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/2/25/PBB_GE_NPLOC4_217796_s_at_fs.png/250px-PBB_GE_NPLOC4_217796_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - ubiquitin binding
- protein binding
- metal ion binding
- ubiquitin protein ligase binding
| Cellular component | - cytoplasm
- cytosol
- nuclear outer membrane-endoplasmic reticulum membrane network
- endoplasmic reticulum
- nucleus
- UFD1-NPL4 complex
- nucleoplasm
- VCP-NPL4-UFD1 AAA ATPase complex
| Biological process | - error-free translesion synthesis
- retrograde protein transport, ER to cytosol
- Golgi organization
- ubiquitin-dependent ERAD pathway
- proteasome-mediated ubiquitin-dependent protein catabolic process
- negative regulation of type I interferon production
- negative regulation of RIG-I signaling pathway
- ubiquitin-dependent protein catabolic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | |
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NP_060391 NP_001356627 NP_060391.2 |
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Location (UCSC) | Chr 17: 81.56 – 81.65 Mb | Chr 11: 120.27 – 120.33 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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