NPRL2

Protein-coding gene in the species Homo sapiens
NPRL2
Identifiers
AliasesNPRL2, NPR2, NPR2L, TUSC4, NPR2-like, GATOR1 complex subunit, FFEVF2, NPR2 like, GATOR1 complex subunit
External IDsOMIM: 607072; MGI: 1914482; HomoloGene: 4771; GeneCards: NPRL2; OMA:NPRL2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for NPRL2
Genomic location for NPRL2
Band3p21.31Start50,347,330 bp[1]
End50,350,826 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for NPRL2
Genomic location for NPRL2
Band9|9 F1Start107,419,425 bp[2]
End107,422,905 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • right hemisphere of cerebellum

  • body of pancreas

  • Skeletal muscle tissue of rectus abdominis

  • muscle of thigh

  • pituitary gland

  • anterior pituitary

  • prefrontal cortex

  • right frontal lobe

  • apex of heart
Top expressed in
  • interventricular septum

  • primary oocyte

  • right kidney

  • proximal tubule

  • spermatocyte

  • neural tube

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • secondary oocyte

  • nucleus of stria terminalis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein kinase activity
  • protein binding
  • GTPase activator activity
Cellular component
  • GATOR1 complex
  • lysosome
  • lysosomal membrane
  • membrane
Biological process
  • negative regulation of TOR signaling
  • cellular response to amino acid starvation
  • negative regulation of kinase activity
  • positive regulation of GTPase activity
  • protein phosphorylation
  • cellular response to nitrogen starvation
  • positive regulation of autophagy
  • regulation of autophagosome assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10641

56032

Ensembl

ENSG00000114388

ENSMUSG00000010057

UniProt

Q8WTW4

Q9WUE4

RefSeq (mRNA)

NM_006545

NM_018879

RefSeq (protein)

NP_006536

NP_061367

Location (UCSC)Chr 3: 50.35 – 50.35 MbChr 9: 107.42 – 107.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114388 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010057 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.
  6. ^ "Entrez Gene: TUSC4 tumor suppressor candidate 4".

Further reading

  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard L, Minna JD, Roth JA, Kundra V, Ji L (Oct 2006). "The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells". Cancer Research. 66 (19): 9682–90. doi:10.1158/0008-5472.CAN-06-1483. PMID 17018626.
  • Li J, Wang F, Haraldson K, Protopopov A, Duh FM, Geil L, Kuzmin I, Minna JD, Stanbridge E, Braga E, Kashuba VI, Klein G, Lerman MI, Zabarovsky ER (Sep 2004). "Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C". Cancer Research. 64 (18): 6438–43. doi:10.1158/0008-5472.CAN-03-3869. PMID 15374952.
  • Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD (May 2002). "Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo". Cancer Research. 62 (9): 2715–20. PMC 3478680. PMID 11980673.


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