NUMBL

Protein-coding gene in the species Homo sapiens

NUMBL
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3F0W

Identifiers
AliasesNUMBL, CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23, NUMB like, endocytic adaptor protein, NUMB like endocytic adaptor protein
External IDsOMIM: 604018; MGI: 894702; HomoloGene: 68413; GeneCards: NUMBL; OMA:NUMBL - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NUMBL
Genomic location for NUMBL
Band19q13.2Start40,665,905 bp[1]
End40,690,972 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for NUMBL
Genomic location for NUMBL
Band7|7 A3Start26,957,858 bp[2]
End26,981,569 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • buccal mucosa cell

  • cardia

  • trigeminal ganglion

  • nipple

  • trachea

  • endothelial cell

  • pylorus

  • ventral tegmental area

  • spinal ganglia
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • ventricular zone

  • lip

  • piriform cortex

  • hippocampus proper

  • ganglionic eminence

  • cerebellar cortex

  • subiculum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
Biological process
  • multicellular organism development
  • positive regulation of neurogenesis
  • neuroblast proliferation
  • forebrain development
  • protein metabolic process
  • adherens junction organization
  • neuroblast division in subventricular zone
  • axonogenesis
  • lateral ventricle development
  • nervous system development
  • cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9253

18223

Ensembl

ENSG00000105245

ENSMUSG00000063160

UniProt

Q9Y6R0

O08919

RefSeq (mRNA)

NM_001289979
NM_001289980
NM_004756

NM_010950

RefSeq (protein)

NP_001276908
NP_001276909
NP_004747

NP_035080

Location (UCSC)Chr 19: 40.67 – 40.69 MbChr 7: 26.96 – 26.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Numb-like protein is a protein that in humans is encoded by the NUMBL gene.[5][6][7]


Interactions

NUMBL has been shown to interact with MAP3K7IP2.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105245 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063160 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
  6. ^ Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP (Oct 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
  7. ^ "Entrez Gene: NUMBL numb homolog (Drosophila)-like".
  8. ^ Ma Q, Zhou Li, Shi Huili, Huo Keke (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. 20 (6). England: 1044–51. doi:10.1016/j.cellsig.2008.01.015. ISSN 0898-6568. PMID 18299187.

Further reading

  • Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168.
  • Zhong W, Feder JN, Jiang MM, et al. (1996). "Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis". Neuron. 17 (1): 43–53. doi:10.1016/S0896-6273(00)80279-2. PMID 8755477.
  • Zhong W, Jiang MM, Weinmaster G, et al. (1997). "Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis". Development. 124 (10): 1887–97. doi:10.1242/dev.124.10.1887. PMID 9169836.
  • Roncarati R, Sestan N, Scheinfeld MH, et al. (2002). "The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7102–7. Bibcode:2002PNAS...99.7102R. doi:10.1073/pnas.102192599. PMC 124535. PMID 12011466.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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