PARP10

Protein-coding gene in the species Homo sapiens

PARP10
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DHX, 3HKV

Identifiers
AliasesPARP10, ARTD10, poly(ADP-ribose) polymerase family member 10
External IDsOMIM: 609564; MGI: 3712326; HomoloGene: 53133; GeneCards: PARP10; OMA:PARP10 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for PARP10
Genomic location for PARP10
Band8q24.3Start143,977,153 bp[1]
End144,012,772 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for PARP10
Genomic location for PARP10
Band15|15 D3Start76,115,374 bp[2]
End76,127,641 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • pancreatic ductal cell

  • right uterine tube

  • spleen

  • appendix

  • lymph node

  • right testis

  • tendon of biceps brachii

  • left testis

  • right lobe of liver
Top expressed in
  • granulocyte

  • thymus

  • right kidney

  • mesenteric lymph nodes

  • duodenum

  • lip

  • spleen

  • proximal tubule

  • left lobe of liver

  • submandibular gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • K63-linked polyubiquitin modification-dependent protein binding
  • protein binding
  • glycosyltransferase activity
  • NAD+ ADP-ribosyltransferase activity
  • protein ADP-ribosylase activity
Cellular component
  • cytoplasm
  • nucleus
  • nucleolus
  • cytosol
  • intracellular membrane-bounded organelle
Biological process
  • negative regulation of protein K63-linked ubiquitination
  • protein auto-ADP-ribosylation
  • negative regulation of NF-kappaB transcription factor activity
  • protein ADP-ribosylation
  • negative regulation of fibroblast proliferation
  • negative regulation of gene expression
  • NAD biosynthesis via nicotinamide riboside salvage pathway
  • protein poly-ADP-ribosylation
  • translesion synthesis
  • protein mono-ADP-ribosylation
  • DNA repair
  • cellular response to DNA damage stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84875

671535

Ensembl

ENSG00000178685

ENSMUSG00000063268

UniProt

Q53GL7

Q8CIE4

RefSeq (mRNA)

NM_032789
NM_001317895

NM_001163575
NM_001163576

RefSeq (protein)

NP_001304824
NP_116178

NP_001157047
NP_001157048

Location (UCSC)Chr 8: 143.98 – 144.01 MbChr 15: 76.12 – 76.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.[5][6]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178685 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063268 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.
  6. ^ a b "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

Further reading

  • Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10)". J. Biol. Chem. 281 (22): 15201–7. doi:10.1074/jbc.M506745200. PMID 16455663.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation". Oncogene. 24 (12): 1982–93. doi:10.1038/sj.onc.1208410. PMID 15674325. S2CID 13330538.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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  • 2dhx: Solution Structure of the RRM Domain in the Human Poly (ADP-ribose) Polymerase Family, Member 10 Variant
    2dhx: Solution Structure of the RRM Domain in the Human Poly (ADP-ribose) Polymerase Family, Member 10 Variant


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