PHF12

Protein-coding gene in the species Homo sapiens

PHF12
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2L9S, 2LKM

Identifiers
AliasesPHF12, PF1, PHD finger protein 12
External IDsMGI: 1924057; HomoloGene: 10841; GeneCards: PHF12; OMA:PHF12 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for PHF12
Genomic location for PHF12
Band17q11.2Start28,905,250 bp[1]
End28,951,771 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for PHF12
Genomic location for PHF12
Band11|11 B5Start77,873,580 bp[2]
End77,921,365 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • granulocyte

  • bone marrow cells

  • stromal cell of endometrium

  • spleen

  • right lung

  • blood

  • appendix

  • gastric mucosa

  • ganglionic eminence
Top expressed in
  • genital tubercle

  • tail of embryo

  • neural layer of retina

  • granulocyte

  • ventricular zone

  • zygote

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • thymus

  • secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transcription corepressor binding
  • histone binding
  • transcription corepressor activity
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • chromatin binding
  • protein binding
  • phosphatidylinositol binding
  • metal ion binding
Cellular component
  • transcription repressor complex
  • Sin3 complex
  • nucleus
  • nucleoplasm
  • Sin3-type complex
Biological process
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57649

268448

Ensembl

ENSG00000109118

ENSMUSG00000037791

UniProt

Q96QT6

Q5SPL2

RefSeq (mRNA)

NM_001033561
NM_001290131
NM_020889

NM_174852

RefSeq (protein)

NP_001028733
NP_001277060
NP_065940

NP_777277

Location (UCSC)Chr 17: 28.91 – 28.95 MbChr 11: 77.87 – 77.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene.[5][6]

Interactions

PHF12 has been shown to interact with SIN3A.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109118 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037791 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yochum GS, Ayer DE (July 2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex". Molecular and Cellular Biology. 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.
  6. ^ "Entrez Gene: PHF12 PHD finger protein 12".

Further reading

  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Yochum GS, Ayer DE (November 2002). "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Molecular and Cellular Biology. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
  • Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. S2CID 43194324.
  • v
  • t
  • e