PJA2

Protein-coding gene in the species Homo sapiens
PJA2
Identifiers
AliasesPJA2, Neurodap1, RNF131, praja ring finger ubiquitin ligase 2
External IDsMGI: 2159342; HomoloGene: 32233; GeneCards: PJA2; OMA:PJA2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for PJA2
Genomic location for PJA2
Band5q21.3Start109,334,713 bp[1]
End109,409,974 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for PJA2
Genomic location for PJA2
Band17|17 E1.1Start64,588,000 bp[2]
End64,638,911 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tail of epididymis

  • postcentral gyrus

  • frontal pole

  • Achilles tendon

  • Brodmann area 46

  • prefrontal cortex

  • orbitofrontal cortex

  • pons

  • caput epididymis

  • superior vestibular nucleus
Top expressed in
  • interventricular septum

  • medial dorsal nucleus

  • dorsal striatum

  • temporal lobe

  • olfactory tubercle

  • globus pallidus

  • inferior colliculus

  • facial motor nucleus

  • Region I of hippocampus proper

  • nucleus accumbens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein kinase A regulatory subunit binding
  • ubiquitin-protein transferase activity
  • protein kinase A catalytic subunit binding
  • ubiquitin protein ligase activity
  • metal ion binding
  • transferase activity
  • protein binding
Cellular component
  • Golgi membrane
  • postsynaptic density
  • membrane
  • endoplasmic reticulum
  • synapse
  • plasma membrane
  • cytoplasm
  • cell junction
  • postsynaptic membrane
  • Golgi apparatus
  • intermediate filament cytoskeleton
  • endoplasmic reticulum membrane
Biological process
  • hippo signaling
  • regulation of protein kinase A signaling
  • long-term memory
  • protein ubiquitination
  • inflammatory response
  • positive regulation of toll-like receptor 2 signaling pathway
  • regulation of macrophage activation
  • innate immune response
  • positive regulation of JNK cascade
  • positive regulation of p38MAPK cascade
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9867

224938

Ensembl

ENSG00000198961

ENSMUSG00000024083

UniProt

O43164

Q80U04

RefSeq (mRNA)

NM_014819

NM_001025309
NM_144859

RefSeq (protein)

NP_055634

NP_001020480
NP_659108

Location (UCSC)Chr 5: 109.33 – 109.41 MbChr 17: 64.59 – 64.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase Praja2 is an enzyme that in humans is encoded by the PJA2 gene.[5]

Interactions

PJA2 has been shown to interact with UBE2D2.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198961 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024083 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PJA2 praja 2, RING-H2 motif containing".
  6. ^ Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
  • Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
  • Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  • Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan WJ, Mishra B (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nakayama M, Miyake T, Gahara Y, Ohara O, Kitamura T (July 1995). "A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse". The Journal of Neuroscience. 15 (7 Pt 2): 5238–48. doi:10.1523/JNEUROSCI.15-07-05238.1995. PMC 6577874. PMID 7623148.


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