PLVAP

Protein-coding gene in the species Homo sapiens
PLVAP
Identifiers
AliasesPLVAP, FELS, PV-1, PV1, gp68, plasmalemma vesicle associated protein, DIAR10
External IDsOMIM: 607647; MGI: 1890497; HomoloGene: 10578; GeneCards: PLVAP; OMA:PLVAP - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PLVAP
Genomic location for PLVAP
Band19p13.11Start17,351,450 bp[1]
End17,377,342 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for PLVAP
Genomic location for PLVAP
Band8 B3.3|8 34.43 cMStart71,950,409 bp[2]
End71,964,396 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • epithelium of colon

  • gallbladder

  • pericardium

  • cardia

  • tendon of biceps brachii

  • subcutaneous adipose tissue

  • spleen

  • fundus
Top expressed in
  • right lung

  • right lung lobe

  • mesenteric lymph nodes

  • atrium

  • right kidney

  • endothelial cell of lymphatic vessel

  • islet of Langerhans

  • left lung

  • spleen

  • internal carotid artery
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein homodimerization activity
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • caveola
  • integral component of membrane
  • cell surface
  • plasma membrane
  • extracellular exosome
  • membrane
Biological process
  • tumor necrosis factor-mediated signaling pathway
  • protein kinase C signaling
  • MAPK cascade
  • positive regulation of cellular extravasation
  • developmental process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83483

84094

Ensembl

ENSG00000130300

ENSMUSG00000034845

UniProt

Q9BX97

Q91VC4

RefSeq (mRNA)

NM_031310

NM_032398

RefSeq (protein)

NP_112600

NP_115774

Location (UCSC)Chr 19: 17.35 – 17.38 MbChr 8: 71.95 – 71.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plasmalemma vesicle-associated protein is a protein that in humans is encoded by the PLVAP gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130300 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034845 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.
  6. ^ "Entrez Gene: PLVAP plasmalemma vesicle associated protein".

Further reading

  • Stan RV, Ghitescu L, Jacobson BS, Palade GE (1999). "Isolation, Cloning, and Localization of Rat PV-1, a Novel Endothelial Caveolar Protein". J. Cell Biol. 145 (6): 1189–98. doi:10.1083/jcb.145.6.1189. PMC 2133139. PMID 10366592.
  • Hnasko R, McFarland M, Ben-Jonathan N (2003). "Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands". J. Endocrinol. 175 (3): 649–61. CiteSeerX 10.1.1.322.5434. doi:10.1677/joe.0.1750649. PMID 12475376.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Stan RV, Tkachenko E, Niesman IR (2005). "PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms". Mol. Biol. Cell. 15 (8): 3615–30. doi:10.1091/mbc.E03-08-0593. PMC 491823. PMID 15155804.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strickland LA, Jubb AM, Hongo JA, et al. (2005). "Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)". J. Pathol. 206 (4): 466–75. doi:10.1002/path.1805. PMID 15971170. S2CID 45045679.
  • Carson-Walter EB, Hampton J, Shue E, et al. (2006). "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis". Clin. Cancer Res. 11 (21): 7643–50. doi:10.1158/1078-0432.CCR-05-1099. PMID 16278383.


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