PPP1R14B

Protein-coding gene in the species Homo sapiens

PPP1R14B
Identifiers
AliasesPPP1R14B, PHI-1, PLCB3N, PNG, SOM172, protein phosphatase 1 regulatory inhibitor subunit 14B
External IDsOMIM: 601140; MGI: 107682; HomoloGene: 7483; GeneCards: PPP1R14B; OMA:PPP1R14B - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PPP1R14B
Genomic location for PPP1R14B
Band11q13.1Start64,244,479 bp[1]
End64,246,943 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for PPP1R14B
Genomic location for PPP1R14B
Band19|19 AStart6,952,336 bp[2]
End6,954,692 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • body of pancreas

  • right coronary artery

  • stromal cell of endometrium

  • apex of heart

  • muscle of thigh

  • mucosa of transverse colon

  • skin of abdomen

  • skin of leg

  • gastrocnemius muscle
Top expressed in
  • ventricular zone

  • lip

  • esophagus

  • yolk sac

  • muscle of thigh

  • nucleus pulposus

  • zygote

  • spermatid

  • embryo

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein phosphatase inhibitor activity
  • phosphatase inhibitor activity
  • protein phosphatase regulator activity
  • protein serine/threonine phosphatase inhibitor activity
Cellular component
  • cytoplasm
Biological process
  • regulation of phosphorylation
  • innate immune response
  • negative regulation of phosphoprotein phosphatase activity
  • negative regulation of catalytic activity
  • regulation of phosphoprotein phosphatase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26472

18938

Ensembl

ENSG00000173457

ENSMUSG00000056612

UniProt

Q96C90

Q62084

RefSeq (mRNA)

NM_138689

NM_008889

RefSeq (protein)

NP_619634

NP_032915

Location (UCSC)Chr 11: 64.24 – 64.25 MbChr 19: 6.95 – 6.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1 regulatory subunit 14B is an enzyme that in humans is encoded by the PPP1R14B gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173457 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056612 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lagercrantz J, Carson E, Larsson C, Nordenskjold M, Weber G (Mar 1997). "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13". Genomics. 31 (3): 380–4. doi:10.1006/geno.1996.0063. PMID 8838322.
  6. ^ Eto M, Karginov A, Brautigan DL (Jan 2000). "A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes". Biochemistry. 38 (51): 16952–7. doi:10.1021/bi992030o. PMID 10606530.
  7. ^ "Entrez Gene: PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B".

Further reading

  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tountas NA, Mandell JW, Everett AD, Brautigan DL (2005). "Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells". Histochem. Cell Biol. 121 (4): 343–50. doi:10.1007/s00418-004-0642-8. PMID 15083373. S2CID 21262452.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tountas NA, Brautigan DL (2005). "Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein". J. Cell Sci. 117 (Pt 24): 5905–12. doi:10.1242/jcs.01506. PMID 15522888. S2CID 2619985.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.


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