Phenylacetate—CoA ligase
Phenylacetate—CoA ligase | |||||||||
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Identifiers | |||||||||
EC no. | 6.2.1.30 | ||||||||
CAS no. | 57219-71-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phenylacetate—CoA ligase is an enzyme (EC 6.2.1.30) that catalyzes the chemical reaction
- ATP + phenylacetate + CoA AMP + diphosphate + phenylacetyl-CoA
The 3 substrates of this enzyme are ATP, phenylacetate, and CoA. Its 3 products are AMP, diphosphate, and phenylacetyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is phenylacetate:CoA ligase (AMP-forming). Other names in common use include phenylacetyl-CoA ligase, PA-CoA ligase, and phenylacetyl-CoA ligase (AMP-forming). This enzyme participates in tyrosine metabolism and phenylalanine metabolism.
References
- Martinez-Blanco H, Reglero A, Rodriguez-Aparicio LB, Luengo JM (1990). "Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid". J. Biol. Chem. 265 (12): 7084–90. PMID 2324116.
- v
- t
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- Aminoacyl tRNA synthetase
- Alanine
- Arginine
- Asparagine
- Aspartate
- Cysteine
- D-alanine—poly(phosphoribitol) ligase
- Glutamate
- Glutamine
- Glycine
- Histidine
- Isoleucine
- Leucine
- Lysine
- Methionine
- Phenylalanine
- Proline
- Serine
- Threonine
- Tryptophan
- Tyrosine
- Valine
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