RAB34

Protein-coding gene in the species Homo sapiens
RAB34
Identifiers
AliasesRAB34, RAB39, RAH, member RAS oncogene family, NARR
External IDsOMIM: 610917; MGI: 104606; HomoloGene: 12908; GeneCards: RAB34; OMA:RAB34 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RAB34
Genomic location for RAB34
Band17q11.2Start28,714,281 bp[1]
End28,718,429 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for RAB34
Genomic location for RAB34
Band11 B5|11 46.74 cMStart78,079,256 bp[2]
End78,083,019 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Descending thoracic aorta

  • left ovary

  • right ovary

  • stromal cell of endometrium

  • canal of the cervix

  • ascending aorta

  • gastric mucosa

  • body of uterus

  • right coronary artery

  • left uterine tube
Top expressed in
  • calvaria

  • internal carotid artery

  • vas deferens

  • external carotid artery

  • condyle

  • brown adipose tissue

  • tunica adventitia of aorta

  • fossa

  • iris

  • molar
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTP-dependent protein binding
  • GTPase activity
Cellular component
  • cytoplasm
  • vesicle
  • phagocytic vesicle membrane
  • Golgi apparatus
  • membrane
  • Golgi cisterna
  • ruffle membrane
  • phagocytic vesicle
  • perinuclear region of cytoplasm
  • Golgi stack
  • extracellular exosome
  • cytoplasmic vesicle
  • cilium
  • cell projection
  • nucleus
  • nucleolus
Biological process
  • antigen processing and presentation
  • phagosome-lysosome fusion
  • phagosome maturation
  • lysosome localization
  • macropinocytosis
  • protein transport
  • protein localization to plasma membrane
  • Golgi to plasma membrane protein transport
  • transport
  • intracellular protein transport
  • cell projection organization
  • Rab protein signal transduction
  • positive regulation of smoothened signaling pathway
  • endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83871

19376

Ensembl

ENSG00000109113

ENSMUSG00000002059

UniProt

Q9BZG1
P0DI83

Q64008

RefSeq (mRNA)
NM_001142624
NM_001142625
NM_001144942
NM_001144943
NM_001256276

NM_001256277
NM_001256278
NM_001256281
NM_031934

NM_001159482
NM_033475

RefSeq (protein)
NP_001136096
NP_001136097
NP_001138414
NP_001138415
NP_001243205

NP_001243206
NP_001243207
NP_001243210
NP_114140
NP_001243210.1

NP_001152954
NP_258436

Location (UCSC)Chr 17: 28.71 – 28.72 MbChr 11: 78.08 – 78.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-34 is a protein that in humans is encoded by the RAB34 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109113 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002059 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sun P, Yamamoto H, Suetsugu S, Miki H, Takenawa T, Endo T (Feb 2003). "Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation". J Biol Chem. 278 (6): 4063–71. doi:10.1074/jbc.M208699200. PMID 12446704.
  6. ^ "Entrez Gene: RAB34 RAB34, member RAS oncogene family".

Further reading

  • Wang T, Hong W (2003). "Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein". Mol. Biol. Cell. 13 (12): 4317–32. doi:10.1091/mbc.E02-05-0280. PMC 138636. PMID 12475955.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chen T, Han Y, Yang M, et al. (2003). "Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis". Biochem. Biophys. Res. Commun. 303 (4): 1114–20. doi:10.1016/S0006-291X(03)00482-0. PMID 12684051.
  • Wang T, Wong KK, Hong W (2004). "A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34". Mol. Biol. Cell. 15 (2): 815–26. doi:10.1091/mbc.E03-06-0413. PMC 329395. PMID 14668488.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction". Biochem. Biophys. Res. Commun. 334 (1): 128–33. doi:10.1016/j.bbrc.2005.06.067. PMID 15996637.
  • Speight P, Silverman M (2005). "Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34". Traffic. 6 (10): 858–65. doi:10.1111/j.1600-0854.2005.00321.x. PMID 16138900.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Coyne CB, Shen L, Turner JR, Bergelson JM (2007). "Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5". Cell Host Microbe. 2 (3): 181–92. doi:10.1016/j.chom.2007.07.003. PMC 2719558. PMID 18005733.


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