RAB37

Protein-coding gene in the species Homo sapiens
RAB37
Identifiers
AliasesRAB37, member RAS oncogene family
External IDsOMIM: 609956; MGI: 1929945; HomoloGene: 23303; GeneCards: RAB37; OMA:RAB37 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RAB37
Genomic location for RAB37
Band17q25.1Start74,670,578 bp[1]
End74,747,335 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for RAB37
Genomic location for RAB37
Band11|11 E2Start114,982,257 bp[2]
End115,053,062 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • granulocyte

  • monocyte

  • blood

  • nasal epithelium

  • spleen

  • bone marrow cells

  • right lobe of liver

  • endothelial cell
Top expressed in
  • islet of Langerhans

  • granulocyte

  • lateral geniculate nucleus

  • anterior horn of spinal cord

  • medial dorsal nucleus

  • medial geniculate nucleus

  • retinal pigment epithelium

  • cerebellar cortex

  • facial motor nucleus

  • lumbar subsegment of spinal cord
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTPase activity
Cellular component
  • cytoplasmic vesicle
  • endoplasmic reticulum-Golgi intermediate compartment
  • azurophil granule membrane
  • specific granule membrane
  • endosome
  • plasma membrane
  • synaptic vesicle
  • secretory granule membrane
  • intracellular anatomical structure
Biological process
  • protein transport
  • neutrophil degranulation
  • vesicle docking involved in exocytosis
  • protein secretion
  • protein localization to plasma membrane
  • regulation of exocytosis
  • intracellular protein transport
  • Rab protein signal transduction
  • small GTPase mediated signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

326624

58222

Ensembl

ENSG00000172794

ENSMUSG00000020732

UniProt

Q96AX2

Q9JKM7

RefSeq (mRNA)
NM_001006637
NM_001006638
NM_001163989
NM_001163990
NM_175738

NM_001330471

NM_001163753
NM_021411

RefSeq (protein)

NP_001006639
NP_001157461
NP_001157462
NP_001317400
NP_783865

NP_001157225
NP_067386

Location (UCSC)Chr 17: 74.67 – 74.75 MbChr 11: 114.98 – 115.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-37 is a protein that in humans is encoded by the RAB37 gene.[5][6]

Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172794 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020732 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Masuda ES, Luo Y, Young C, Shen M, Rossi AB, Huang BC, Yu S, Bennett MK, Payan DG, Scheller RH (May 2000). "Rab37 is a novel mast cell specific GTPase localized to secretory granules". FEBS Lett. 470 (1): 61–4. doi:10.1016/S0014-5793(00)01288-6. PMID 10722846. S2CID 38218555.
  6. ^ a b "Entrez Gene: RAB37 RAB37, member RAS oncogene family".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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