RAB3D

Protein-coding gene in the species Homo sapiens

RAB3D

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2GF9

Identifiers

Aliases

RAB3D, D2-2, GOV, RAB16, RAD3D, member RAS oncogene family

External IDs

OMIM: 604350; MGI: 97844; HomoloGene: 20902; GeneCards: RAB3D; OMA:RAB3D - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.2	Start	11,322,068 bp^[1]
Band	19p13.2	End	11,346,270 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A3	Start	21,818,787 bp^[2]
Band	9\|9 A3	End	21,829,488 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

spinal ganglia

human penis

nipple

skin of thigh

mucosa of pharynx

vulva

blood

cardia

trigeminal ganglion

Top expressed in

lacrimal gland

granulocyte

salivary gland

lumbar spinal ganglion

epithelium of stomach

corneal stroma

submandibular gland

pyloric antrum

parotid gland

conjunctival fornix

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GTP binding myosin V binding GTP-dependent protein binding GTPase activity
Cellular component	zymogen granule cytoplasmic microtubule secretory vesicle extracellular exosome transport vesicle mitochondrion membrane plasma membrane azurophil granule membrane endosome synaptic vesicle vesicle
Biological process	regulation of exocytosis protein transport peptidyl-cysteine methylation bone resorption positive regulation of regulated secretory pathway exocytosis neutrophil degranulation transport intracellular protein transport vesicle docking involved in exocytosis protein secretion Rab protein signal transduction protein localization to plasma membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9545


19340

Ensembl


ENSG00000105514


ENSMUSG00000019066

UniProt


O95716


P35276

RefSeq (mRNA)


NM_004283


NM_031874 NM_001324531

RefSeq (protein)


NP_004274


NP_001311460 NP_114080

Location (UCSC)

Chr 19: 11.32 – 11.35 Mb

Chr 9: 21.82 – 21.83 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-3D is a protein that in humans is encoded by the RAB3D gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105514 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishio H, Suda T, Sawada K, Miyamoto T, Koike T, Yamaguchi Y (Mar 1999). "Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation". Biochim Biophys Acta. 1444 (2): 283–90. doi:10.1016/s0167-4781(98)00279-6. PMID 10023084.
^ Chen XN, Shi ZY, Korenberg JR, Sehgal A (Mar 1999). "Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 230–1. doi:10.1159/000015187. PMID 10072586. S2CID 24430172.
^ "Entrez Gene: RAB3D RAB3D, member RAS oncogene family".

Brondyk WH, McKiernan CJ, Fortner KA, et al. (1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol. Cell. Biol. 15 (3): 1137–43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276.
Sehgal A, Keener C, Boynton AL, et al. (1997). "Isolation and characterization of a novel gene from human glioblastoma multiforme tumor tissue". Int. J. Cancer. 71 (4): 565–72. doi:10.1002/(SICI)1097-0215(19970516)71:4<565::AID-IJC10>3.0.CO;2-B. PMID 9178809.
Raffaniello RD, Raufman JP (1999). "Cytosolic RAB3D is associated with RAB escort protein (REP), not RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from guinea pig stomach". J. Cell. Biochem. 72 (4): 540–8. doi:10.1002/(SICI)1097-4644(19990315)72:4<540::AID-JCB9>3.0.CO;2-D. PMID 10022613. S2CID 35820873.
Cartel NJ, Wang J, Post M (2002). "Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt". Biochem. J. 363 (Pt 1): 19–28. doi:10.1042/0264-6021:3630019. PMC 1222446. PMID 11903042.
Riedel D, Antonin W, Fernandez-Chacon R, et al. (2002). "Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules". Mol. Cell. Biol. 22 (18): 6487–97. doi:10.1128/MCB.22.18.6487-6497.2002. PMC 135623. PMID 12192047.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Nguyen D, Jones A, Ojakian GK, et al. (2003). "Rab3D redistribution and function in rat parotid acini". J. Cell. Physiol. 197 (3): 400–8. doi:10.1002/jcp.10373. PMID 14566969. S2CID 33152672.
Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Knop M, Aareskjold E, Bode G, Gerke V (2005). "Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells". EMBO J. 23 (15): 2982–92. doi:10.1038/sj.emboj.7600319. PMC 514934. PMID 15257287.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.