RAP1A |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1C1Y, 1GUA, 3KUC, 4KVG |
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Identifiers |
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Aliases | RAP1A, C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21, member of RAS oncogene family |
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External IDs | OMIM: 179520; MGI: 97852; HomoloGene: 2162; GeneCards: RAP1A; OMA:RAP1A - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1p13.2 | Start | 111,542,218 bp[1] |
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End | 111,716,691 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3 F2.2|3 46.45 cM | Start | 105,634,583 bp[2] |
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End | 105,708,652 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - monocyte
- tail of epididymis
- superficial temporal artery
- popliteal artery
- tibial arteries
- jejunal mucosa
- muscle layer of sigmoid colon
- gastric mucosa
- saphenous vein
- right ventricle
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| Top expressed in | - tail of embryo
- genital tubercle
- jejunum
- granulocyte
- esophagus
- stomach
- thymus
- placenta
- dentate gyrus of hippocampal formation granule cell
- duodenum
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - nucleotide binding
- protein-containing complex binding
- GTP binding
- protein binding
- GTPase activity
- GDP binding
| Cellular component | - cytosol
- endosome
- membrane
- myelin sheath
- plasma membrane
- guanyl-nucleotide exchange factor complex
- neuron projection
- extracellular exosome
- early endosome
- late endosome
- cytoplasm
- cell junction
- perinuclear region of cytoplasm
- specific granule membrane
- phagocytic vesicle
- glutamatergic synapse
| Biological process | - establishment of endothelial barrier
- positive regulation of glucose import
- microvillus assembly
- regulation of cell junction assembly
- regulation of insulin secretion
- small GTPase mediated signal transduction
- Rap protein signal transduction
- cellular response to organic cyclic compound
- nervous system development
- negative regulation of synaptic vesicle exocytosis
- liver regeneration
- protein transport
- response to antineoplastic agent
- response to carbohydrate
- negative regulation of collagen biosynthetic process
- cellular response to glucose stimulus
- signal transduction
- cellular response to nerve growth factor stimulus
- nerve growth factor signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein kinase activity
- positive regulation of vasculogenesis
- positive regulation of GTPase activity
- cellular response to cAMP
- positive regulation of neuron projection development
- neutrophil degranulation
- positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
- protein localization to plasma membrane
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001010935 NM_001291896 NM_002884 NM_001370216 NM_001370217
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NM_001394066 |
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RefSeq (protein) | |
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NP_001010935 NP_001278825 NP_002875 NP_001357145 NP_001357146 |
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Location (UCSC) | Chr 1: 111.54 – 111.72 Mb | Chr 3: 105.63 – 105.71 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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