RASAL3

Protein-coding gene in the species Homo sapiens
RASAL3
Identifiers
AliasesRASAL3, RAS protein activator like 3
External IDsOMIM: 616561; MGI: 2444128; HomoloGene: 18901; GeneCards: RASAL3; OMA:RASAL3 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for RASAL3
Genomic location for RASAL3
Band19p13.12Start15,451,624 bp[1]
End15,464,544 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for RASAL3
Genomic location for RASAL3
Band17|17 B1Start32,609,633 bp[2]
End32,622,557 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • spleen

  • lymph node

  • appendix

  • blood

  • bone marrow cells

  • mucosa of ileum

  • thymus

  • monocyte

  • upper lobe of left lung
Top expressed in
  • thymus

  • mesenteric lymph nodes

  • granulocyte

  • blood

  • spleen

  • subcutaneous adipose tissue

  • spermatocyte

  • pharynx

  • embryo

  • tibiofemoral joint
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • GTPase activator activity
Cellular component
  • cytosol
  • membrane
  • intrinsic component of the cytoplasmic side of the plasma membrane
  • cytoplasmic side of membrane
  • cell cortex
  • extracellular exosome
  • cytoplasm
Biological process
  • regulation of GTPase activity
  • MAPK cascade
  • positive regulation of NK T cell proliferation
  • signal transduction
  • negative regulation of Ras protein signal transduction
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64926

320484

Ensembl

ENSG00000105122

ENSMUSG00000052142

UniProt

Q86YV0

Q8C2K5

RefSeq (mRNA)
NM_022904
NM_001348027
NM_001348028
NM_001400377
NM_001400378

NM_001400379
NM_001400380
NM_001400381

NM_178785
NM_001347343
NM_001374604
NM_001400382

RefSeq (protein)

NP_075055
NP_001334956
NP_001334957

NP_001334272
NP_848900
NP_001361533
NP_001387311

Location (UCSC)Chr 19: 15.45 – 15.46 MbChr 17: 32.61 – 32.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAS protein activator like 3 is a protein that in humans is encoded by the RASAL3 gene. [5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105122 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052142 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RAS protein activator like 3". Retrieved 2016-07-16.

Further reading

  • Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita-Takahashi M, Yamazaki M, Abe M, Sakimura K, Kanda Y, Kawamura H, Jiang S, Naito M, Yoshizaki T, Takahashi M, Fujii M (2015). "RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells". Eur. J. Immunol. 45 (5): 1512–23. doi:10.1002/eji.201444977. PMID 25652366.


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