RNF135

Protein-coding gene in the species Homo sapiens
RNF135
Identifiers
AliasesRNF135, MMFD, REUL, Riplet, L13, ring finger protein 135
External IDsOMIM: 611358; MGI: 1919206; HomoloGene: 12427; GeneCards: RNF135; OMA:RNF135 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RNF135
Genomic location for RNF135
Band17q11.2Start30,970,984 bp[1]
End30,999,911 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for RNF135
Genomic location for RNF135
Band11 B5|11 47.59 cMStart80,074,677 bp[2]
End80,090,583 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • parietal pleura

  • synovial membrane

  • visceral pleura

  • skin of arm

  • mucosa of ileum

  • secondary oocyte

  • gingival epithelium

  • human penis

  • synovial joint
Top expressed in
  • proximal tubule

  • right kidney

  • epithelium of small intestine

  • granulocyte

  • interventricular septum

  • utricle

  • left lobe of liver

  • spleen

  • lacrimal gland

  • ciliary body
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ribonucleoprotein complex binding
  • protein binding
  • metal ion binding
  • ubiquitin-protein transferase activity
  • identical protein binding
  • transferase activity
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • positive regulation of interferon-beta production
  • negative regulation of type I interferon production
  • innate immune response
  • regulation of innate immune response
  • protein ubiquitination
  • immune system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84282

71956

Ensembl

ENSG00000181481

ENSMUSG00000020707

UniProt

Q8IUD6

Q9CWS1

RefSeq (mRNA)

NM_001184992
NM_032322
NM_197939

NM_028019

RefSeq (protein)

NP_001171921
NP_115698
NP_922921

NP_082295

Location (UCSC)Chr 17: 30.97 – 31 MbChr 11: 80.07 – 80.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.[5][6][7]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions

RNF135 has been shown to interact with RARRES3.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181481 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020707 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–27. doi:10.1086/323043. PMC 1235482. PMID 11468690.
  6. ^ a b Oshiumi H, Matsumoto M, Hatakeyama S, Seya T (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem. 284 (2): 807–17. doi:10.1074/jbc.M804259200. PMID 19017631.
  7. ^ a b "Entrez Gene: RNF135 ring finger protein 135".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse". Genes Chromosomes Cancer. 37 (2): 111–20. doi:10.1002/gcc.10206. PMID 12696059. S2CID 37232718.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.


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