RNF5

Protein-coding gene in the species Homo sapiens

RNF5

Identifiers

Aliases

RNF5, RING5, RMA1, ring finger protein 5

External IDs

OMIM: 602677; MGI: 1860076; HomoloGene: 56004; GeneCards: RNF5; OMA:RNF5 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.32	Start	32,178,405 bp^[1]
Band	6p21.32	End	32,180,793 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 B1\|17 18.18 cM	Start	34,820,065 bp^[2]
Band	17 B1\|17 18.18 cM	End	34,822,664 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

human kidney

ventricular zone

right adrenal gland

mucosa of transverse colon

right adrenal cortex

monocyte

apex of heart

left ventricle

duodenum

Top expressed in

proximal tubule

right kidney

neural tube

neural layer of retina

yolk sac

ganglionic eminence

human kidney

pons

brown adipose tissue

olfactory bulb

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	metal ion binding ubiquitin-protein transferase activity protein binding ubiquitin-like protein conjugating enzyme binding transferase activity identical protein binding zinc ion binding ubiquitin protein ligase activity protein-containing complex binding
Cellular component	integral component of membrane mitochondrial membranes membrane mitochondrion Derlin-1 retrotranslocation complex endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum quality control compartment
Biological process	response to bacterium protein K63-linked ubiquitination ER-associated misfolded protein catabolic process regulation of autophagosome assembly protein K48-linked ubiquitination protein destabilization protein ubiquitination negative regulation of autophagy transmembrane transport endoplasmic reticulum mannose trimming ubiquitin-dependent ERAD pathway ERAD pathway ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6048


54197

Ensembl

ENSG00000227277 ENSG00000223767 ENSG00000228907 ENSG00000183574 ENSG00000204308
ENSG00000225452 ENSG00000228405


ENSMUSG00000015478

UniProt


Q99942


O35445

RefSeq (mRNA)


NM_006913


NM_019403

RefSeq (protein)


NP_008844


NP_062276

Location (UCSC)

Chr 6: 32.18 – 32.18 Mb

Chr 17: 34.82 – 34.82 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene.^[5]^[6]

Function

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.^[6]

References

^ ^a ^b ^c ENSG00000223767, ENSG00000228907, ENSG00000183574, ENSG00000204308, ENSG00000225452, ENSG00000228405 GRCh38: Ensembl release 89: ENSG00000227277, ENSG00000223767, ENSG00000228907, ENSG00000183574, ENSG00000204308, ENSG00000225452, ENSG00000228405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015478 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kyushiki H, Kuga Y, Suzuki M, Takahashi E, Horie M (Apr 1998). "Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans". Cytogenetics and Cell Genetics. 79 (1–2): 114–7. doi:10.1159/000134695. PMID 9533025.
^ ^a ^b "Entrez Gene: RNF5 ring finger protein 5".

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