RUNDC3A

Protein-coding gene in humans
RUNDC3A
Identifiers
AliasesRUNDC3A, RAP2IP, RPIP-8, RPIP8, RUN domain containing 3A
External IDsOMIM: 605448; MGI: 1858752; HomoloGene: 4871; GeneCards: RUNDC3A; OMA:RUNDC3A - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RUNDC3A
Genomic location for RUNDC3A
Band17q21.31Start44,308,413 bp[1]
End44,318,670 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for RUNDC3A
Genomic location for RUNDC3A
Band11|11 DStart102,284,229 bp[2]
End102,293,381 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • right hemisphere of cerebellum

  • cingulate gyrus

  • anterior cingulate cortex

  • prefrontal cortex

  • Brodmann area 9

  • amygdala

  • nucleus accumbens

  • caudate nucleus

  • hippocampus proper
Top expressed in
  • neural layer of retina

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • cerebellar cortex

  • entorhinal cortex

  • perirhinal cortex

  • CA3 field

  • primary motor cortex

  • lobe of cerebellum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • guanylate cyclase activator activity
  • GTPase regulator activity
  • peptide hormone receptor binding
Cellular component
  • cytosol
  • plasma membrane
Biological process
  • small GTPase mediated signal transduction
  • positive regulation of guanylate cyclase activity
  • regulation of catalytic activity
  • positive regulation of cGMP-mediated signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10900

51799

Ensembl

ENSG00000108309

ENSMUSG00000006575

UniProt

Q59EK9

O08576

RefSeq (mRNA)

NM_001144825
NM_001144826
NM_006695

NM_001252347
NM_016759
NM_001362803
NM_001362804

RefSeq (protein)

NP_001138297
NP_001138298
NP_006686

NP_001239276
NP_058039
NP_001349732
NP_001349733

Location (UCSC)Chr 17: 44.31 – 44.32 MbChr 11: 102.28 – 102.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RUN domain-containing protein 3A is a protein that in humans is encoded by the RUNDC3A gene.[5][6]

Interactions

RUNDC3A has been shown to interact with RAP2A.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108309 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006575 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Apr 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". Eur. J. Biochem. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
  6. ^ "Entrez Gene: RPIP8 RaP2 interacting protein 8".

Further reading

  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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