SAFB2

Protein-coding gene in the species Homo sapiens
SAFB2
Identifiers
AliasesSAFB2, scaffold attachment factor B2
External IDsOMIM: 608066; MGI: 2146808; HomoloGene: 35210; GeneCards: SAFB2; OMA:SAFB2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SAFB2
Genomic location for SAFB2
Band19p13.3Start5,586,999 bp[1]
End5,624,046 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for SAFB2
Genomic location for SAFB2
Band17|17 DStart56,560,965 bp[2]
End56,584,585 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • anterior pituitary

  • right uterine tube

  • left ovary

  • right ovary

  • sural nerve

  • canal of the cervix

  • body of uterus

  • right lobe of thyroid gland

  • left lobe of thyroid gland
Top expressed in
  • neural layer of retina

  • granulocyte

  • ventricular zone

  • yolk sac

  • superior frontal gyrus

  • tail of embryo

  • thymus

  • lip

  • primary visual cortex

  • muscle of thigh
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • nucleic acid binding
  • identical protein binding
  • protein binding
  • double-stranded DNA binding
  • RNA binding
  • sequence-specific DNA binding
Cellular component
  • extracellular exosome
  • nucleoplasm
  • cytoplasm
  • intracellular membrane-bounded organelle
  • nucleus
  • nuclear body
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • Sertoli cell differentiation
  • regulation of transcription by RNA polymerase II
  • regulation of androgen receptor signaling pathway
  • regulation of mRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9667

224902

Ensembl

ENSG00000130254

ENSMUSG00000042625

UniProt

Q14151

Q80YR5

RefSeq (mRNA)

NM_014649

NM_001029979
NM_001355463

RefSeq (protein)

NP_055464

NP_001025150
NP_001342392

Location (UCSC)Chr 19: 5.59 – 5.62 MbChr 17: 56.56 – 56.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.[5][6]

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha[5] and SAFB.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130254 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042625 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.
  6. ^ "Entrez Gene: SAFB2 scaffold attachment factor B2".

Further reading

  • Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID 14587024. S2CID 39178501.
  • Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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