SECTM1

Protein-coding gene in the species Homo sapiens

SECTM1
Identifiers
AliasesSECTM1, K12, secreted and transmembrane 1, SECTM
External IDsOMIM: 602602; MGI: 2384805; HomoloGene: 134112; GeneCards: SECTM1; OMA:SECTM1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SECTM1
Genomic location for SECTM1
Band17q25.3Start82,321,024 bp[1]
End82,334,074 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SECTM1
Genomic location for SECTM1
Band11|11 E2Start120,958,233 bp[2]
End120,972,046 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • granulocyte

  • blood

  • mucosa of transverse colon

  • mucosa of ileum

  • jejunal mucosa

  • duodenum

  • spleen

  • appendix

  • decidua
Top expressed in
  • skin of external ear

  • epithelium of stomach

  • epithelium of small intestine

  • seminal vesicula

  • mucous cell of stomach

  • lip

  • right kidney

  • duodenum

  • jejunum

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • cytokine activity
Cellular component
  • extracellular region
  • Golgi apparatus
  • plasma membrane
  • membrane
  • extracellular exosome
  • integral component of membrane
  • extracellular space
Biological process
  • mesoderm development
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • immune response
  • signal transduction
  • regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6398

209588

Ensembl

ENSG00000141574

ENSMUSG00000025165

UniProt

Q8WVN6

Q921W8

RefSeq (mRNA)

NM_003004

NM_145373

RefSeq (protein)

NP_002995

n/a

Location (UCSC)Chr 17: 82.32 – 82.33 MbChr 11: 120.96 – 120.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secreted and transmembrane protein 1 is a protein that in humans is encoded by the SECTM1 gene.[5][6]

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141574 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025165 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Slentz-Kesler KA, Hale LP, Kaufman RE (Apr 1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms". Genomics. 47 (3): 327–40. doi:10.1006/geno.1997.5151. PMID 9480746.
  6. ^ a b "Entrez Gene: SECTM1 secreted and transmembrane 1".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lyman SD, Escobar S, Rousseau AM, et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein". J. Biol. Chem. 275 (5): 3431–7. doi:10.1074/jbc.275.5.3431. PMID 10652336.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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