SEMA4B

Protein-coding gene in the species Homo sapiens
SEMA4B
Identifiers
AliasesSEMA4B, SEMAC, SemC, semaphorin 4B
External IDsOMIM: 617029; MGI: 107559; HomoloGene: 8426; GeneCards: SEMA4B; OMA:SEMA4B - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SEMA4B
Genomic location for SEMA4B
Band15q26.1Start90,160,604 bp[1]
End90,229,679 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SEMA4B
Genomic location for SEMA4B
Band7|7 D2Start79,836,589 bp[2]
End79,876,275 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • mucosa of esophagus

  • secondary oocyte

  • muscle layer of sigmoid colon

  • olfactory zone of nasal mucosa

  • gums

  • vagina

  • transverse colon

  • gingival epithelium

  • right lobe of thyroid gland
Top expressed in
  • cumulus cell

  • external carotid artery

  • submandibular gland

  • ciliary body

  • internal carotid artery

  • lumbar spinal ganglion

  • lip

  • Rostral migratory stream

  • yolk sac

  • blood
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • neuropilin binding
  • semaphorin receptor binding
  • chemorepellent activity
Cellular component
  • integral component of membrane
  • membrane
  • extracellular space
  • plasma membrane
  • integral component of plasma membrane
Biological process
  • multicellular organism development
  • cell differentiation
  • nervous system development
  • negative chemotaxis
  • neural crest cell migration
  • positive regulation of cell migration
  • negative regulation of axon extension involved in axon guidance
  • semaphorin-plexin signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10509

20352

Ensembl

ENSG00000185033

ENSMUSG00000030539

UniProt

Q9NPR2

Q62179

RefSeq (mRNA)
NM_020210
NM_198925
NM_001324029
NM_001324030
NM_001324031

NM_001324032
NM_001324034
NM_001393916

NM_013659
NM_001360135

RefSeq (protein)
NP_001310958
NP_001310959
NP_001310960
NP_001310961
NP_001310962

NP_001310963
NP_064595
NP_945119

NP_038687
NP_001347064

Location (UCSC)Chr 15: 90.16 – 90.23 MbChr 7: 79.84 – 79.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185033 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030539 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
  6. ^ "Entrez Gene: SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B".

Further reading

  • Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  • Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


  • v
  • t
  • e