SFRS14

Protein-coding gene in the species Homo sapiens
SUGP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1X4P

Identifiers
AliasesSUGP2, SFRS14, SURP and G-patch domain containing 2, SRFS14
External IDsOMIM: 607993; MGI: 2678085; HomoloGene: 8923; GeneCards: SUGP2; OMA:SUGP2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SUGP2
Genomic location for SUGP2
Band19p13.11Start18,990,888 bp[1]
End19,034,023 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for SUGP2
Genomic location for SUGP2
Band8|8 B3.3Start70,234,226 bp[2]
End70,279,915 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • cerebellar hemisphere

  • right testis

  • right hemisphere of cerebellum

  • primary visual cortex

  • middle temporal gyrus

  • anterior pituitary

  • ventricular zone

  • right frontal lobe

  • left lobe of thyroid gland
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • neural layer of retina

  • barrel cortex

  • superior cervical ganglion

  • Rostral migratory stream

  • external carotid artery

  • anterior amygdaloid area

  • ventromedial nucleus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • nucleic acid binding
  • RNA binding
Cellular component
  • nucleus
  • nucleoplasm
  • nuclear body
Biological process
  • mRNA processing
  • RNA processing
  • RNA splicing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10147

234373

Ensembl

ENSG00000064607

ENSMUSG00000036054

UniProt

Q8IX01

Q8CH09

RefSeq (mRNA)
NM_001017392
NM_014884
NM_001321697
NM_001321698
NM_001321699

NM_001352071

NM_001168290
NM_172755

RefSeq (protein)
NP_001017392
NP_001308626
NP_001308627
NP_001308628
NP_055699

NP_001339000

NP_001161762
NP_766343

Location (UCSC)Chr 19: 18.99 – 19.03 MbChr 8: 70.23 – 70.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Putative splicing factor, arginine/serine-rich 14 is a protein that in humans is encoded by the SFRS14 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064607 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036054 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sampson ND, Hewitt JE (Feb 2003). "SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11". Gene. 305 (1): 91–100. doi:10.1016/S0378-1119(02)01230-1. PMID 12594045.
  6. ^ "Entrez Gene: SFRS14 splicing factor, arginine/serine-rich 14".

Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  • v
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  • 1x4p: Solution structure of SURP domain in SFRS14 protei
    1x4p: Solution structure of SURP domain in SFRS14 protei


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