SHC2

Protein-coding gene in the species Homo sapiens
SHC2
Identifiers
AliasesSHC2, SCK, SHCB, SLI, SHC adaptor protein 2
External IDsOMIM: 605217; MGI: 106180; HomoloGene: 19127; GeneCards: SHC2; OMA:SHC2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SHC2
Genomic location for SHC2
Band19p13.3Start416,589 bp[1]
End461,033 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SHC2
Genomic location for SHC2
Band10 C1|10 39.72 cMStart79,453,885 bp[2]
End79,473,752 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • anterior pituitary

  • right lobe of liver

  • right uterine tube

  • gastric mucosa

  • apex of heart

  • right frontal lobe

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • amygdala
Top expressed in
  • superior cervical ganglion

  • lumbar spinal ganglion

  • primary visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • neural tube

  • genital tubercle

  • muscle of thigh

  • tail of embryo

  • humerus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • receptor tyrosine kinase binding
Cellular component
  • cytosol
  • plasma membrane
  • cellular component
Biological process
  • Ras protein signal transduction
  • vascular endothelial growth factor receptor signaling pathway
  • MAPK cascade
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • intracellular signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25759

216148

Ensembl

ENSG00000129946

ENSMUSG00000020312

UniProt

P98077

Q8BMC3

RefSeq (mRNA)

NM_012435
NM_001387056

NM_001024539

RefSeq (protein)

NP_036567

NP_001019710

Location (UCSC)Chr 19: 0.42 – 0.46 MbChr 10: 79.45 – 79.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.[5][6][7]


Interactions

SHC2 has been shown to interact with Kinase insert domain receptor.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129946 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020312 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kavanaugh WM; Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862–5. Bibcode:1994Sci...266.1862K. doi:10.1126/science.7527937. PMID 7527937.
  6. ^ Nakamura T; Muraoka S; Sanokawa R; Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
  7. ^ "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2".
  8. ^ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. 347 (Pt 2). England: 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680.

Further reading

  • Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Liu HY; Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
  • Warner AJ, Lopez-Dee J, Knight EL, et al. (2001). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. PMC 1220983. PMID 10749680.
  • Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID 8760305.


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