SHCBP1

Protein-coding gene in the species Homo sapiens

SHCBP1
Identifiers
AliasesSHCBP1, PAL, SHC binding and spindle associated 1
External IDsOMIM: 611027; MGI: 1338802; HomoloGene: 32123; GeneCards: SHCBP1; OMA:SHCBP1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for SHCBP1
Genomic location for SHCBP1
Band16q11.2Start46,578,591 bp[1]
End46,621,379 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for SHCBP1
Genomic location for SHCBP1
Band8|8 A1.1Start4,785,976 bp[2]
End4,829,567 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • ventricular zone

  • bone marrow

  • gonad

  • ganglionic eminence

  • trabecular bone

  • stromal cell of endometrium

  • bone marrow cells

  • appendix

  • testicle
Top expressed in
  • otic placode

  • otic vesicle

  • saccule

  • primitive streak

  • maxillary prominence

  • mandibular prominence

  • abdominal wall

  • condyle

  • vas deferens

  • dermis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • SH2 domain binding
  • protein binding
Cellular component
  • cytoskeleton
  • cytoplasm
  • spindle
  • midbody
Biological process
  • regulation of neural precursor cell proliferation
  • fibroblast growth factor receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79801

20419

Ensembl

ENSG00000171241

ENSMUSG00000022322

UniProt

Q8NEM2

Q9Z179

RefSeq (mRNA)

NM_024745
NM_001324318
NM_001324319

NM_011369

RefSeq (protein)

NP_001311247
NP_001311248
NP_079021

NP_035499

Location (UCSC)Chr 16: 46.58 – 46.62 MbChr 8: 4.79 – 4.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SHC SH2 domain-binding protein 1 is a protein that in humans is encoded by the SHCBP1 gene.[5][6]

Interactions

SHCBP1 has been shown to interact with SHC1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171241 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022322 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Schmandt R, Liu SK, McGlade CJ (Mar 1999). "Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells". Oncogene. 18 (10): 1867–1879. doi:10.1038/sj.onc.1202507. PMID 10086341. S2CID 21481825.
  6. ^ "Entrez Gene: SHCBP1 SHC SH2-domain binding protein 1".

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–120. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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