SNAPC2

Protein-coding gene in the species Homo sapiens
SNAPC2
Identifiers
AliasesSNAPC2, PTFDELTA, SNAP45, small nuclear RNA activating complex polypeptide 2
External IDsOMIM: 605076; MGI: 1914861; HomoloGene: 2318; GeneCards: SNAPC2; OMA:SNAPC2 - orthologs
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[1]
Chromosome 8 (mouse)
Genomic location for SNAPC2
Genomic location for SNAPC2
Band8|8 A1.1Start4,303,080 bp[1]
End4,306,220 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • left uterine tube

  • popliteal artery

  • gastric mucosa

  • canal of the cervix

  • ascending aorta

  • right coronary artery

  • left coronary artery

  • anterior pituitary

  • nucleus accumbens
Top expressed in
  • internal carotid artery

  • external carotid artery

  • ankle

  • right ventricle

  • vas deferens

  • epithelium of lens

  • medial ganglionic eminence

  • fossa

  • condyle

  • efferent ductule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
  • nuclear body
Biological process
  • snRNA transcription
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • transcription by RNA polymerase III
  • snRNA transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6618

102209

Ensembl

n/a

ENSMUSG00000011837

UniProt

Q13487

Q91XA5

RefSeq (mRNA)

NM_003083

NM_133968

RefSeq (protein)

NP_003074

NP_598729

Location (UCSC)n/aChr 8: 4.3 – 4.31 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

snRNA-activating protein complex subunit 2 is a protein that in humans is encoded by the SNAPC2 gene.[4][5]


Interactions

SNAPC2 has been shown to interact with SNAPC4.[6][7]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011837 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Sadowski CL, Henry RW, Kobayashi R, Hernandez N (April 1996). "The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (9): 4289–93. Bibcode:1996PNAS...93.4289S. doi:10.1073/pnas.93.9.4289. PMC 39528. PMID 8633057.
  5. ^ "Entrez Gene: SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa".
  6. ^ Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Molecular and Cellular Biology. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
  7. ^ Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.

Further reading

  • Henry RW, Sadowski CL, Kobayashi R, Hernandez N (April 1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III". Nature. 374 (6523): 653–6. Bibcode:1995Natur.374..653H. doi:10.1038/374653a0. PMID 7715707. S2CID 4325527.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Yoon JB, Roeder RG (January 1996). "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein". Molecular and Cellular Biology. Advances in Molecular and Cell Biology. 16 (1): 1–9. doi:10.1016/S1569-2558(08)60061-2. ISBN 978-0-7623-0143-0. PMC 230972. PMID 8524284.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Molecular and Cellular Biology. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
  • Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
  • Acierno JS, Kennedy JC, Falardeau JL, Leyne M, Bromley MC, Colman MW, Sun M, Bove C, Ashworth LK, Chadwick LH, Schiripo T, Ma S, Goldin E, Schiffmann R, Slaugenhaupt SA (April 2001). "A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2". Genomics. 73 (2): 203–10. doi:10.1006/geno.2001.6526. PMID 11318610.
  • Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW (May 2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". The Journal of Biological Chemistry. 278 (20): 18649–57. doi:10.1074/jbc.M204247200. PMID 12621023.


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