SPACA3

Protein-coding gene in the species Homo sapiens
SPACA3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4YF2

Identifiers
AliasesSPACA3, 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1, LYZC, sperm acrosome associated 3
External IDsOMIM: 612749; MGI: 1922872; HomoloGene: 18365; GeneCards: SPACA3; OMA:SPACA3 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SPACA3
Genomic location for SPACA3
Band17q11.2Start32,970,376 bp[1]
End32,997,877 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SPACA3
Genomic location for SPACA3
Band11|11 B5Start80,749,191 bp[2]
End80,758,640 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • sperm

  • testicle

  • body of pancreas

  • gonad

  • mucosa of transverse colon

  • right coronary artery

  • tibial nerve

  • granulocyte
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • lacrimal gland

  • morula

  • pancreas

  • cochlea

  • islet of Langerhans

  • foregut

  • stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • lysozyme activity
Cellular component
  • integral component of membrane
  • extracellular region
  • acrosomal vesicle
  • secretory granule
  • membrane
  • cytoplasmic vesicle
  • extracellular space
  • acrosomal membrane
  • acrosomal matrix
Biological process
  • monocyte activation
  • cell wall macromolecule catabolic process
  • fertilization
  • positive regulation of phagocytosis
  • response to virus
  • positive regulation of macrophage activation
  • sperm-egg recognition
  • defense response to Gram-positive bacterium
  • peptidoglycan catabolic process
  • defense response to Gram-negative bacterium
  • fusion of sperm to egg plasma membrane involved in single fertilization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

124912

75622

Ensembl

ENSG00000141316

ENSMUSG00000053184

UniProt

Q8IXA5

Q9D9X8

RefSeq (mRNA)

NM_173847
NM_001317225
NM_001317226

NM_029367
NM_001359183

RefSeq (protein)

NP_001304154
NP_001304155
NP_776246

NP_083643
NP_001346112

Location (UCSC)Chr 17: 32.97 – 33 MbChr 11: 80.75 – 80.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141316 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053184 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (Apr 2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa". Biol Reprod. 68 (5): 1525–37. doi:10.1095/biolreprod.102.010108. PMID 12606493.
  6. ^ "Entrez Gene: SPACA3 sperm acrosome associated 3".

Further reading

  • Niyonsaba F, Ogawa H (2006). "Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme". J. Dermatol. Sci. 40 (3): 157–68. doi:10.1016/j.jdermsci.2005.07.009. PMID 16150577.
  • Cramer EM, Breton-Gorius J (1987). "Ultrastructural localization of lysozyme in human neutrophils by immunogold". J. Leukoc. Biol. 41 (3): 242–7. doi:10.1002/jlb.41.3.242. PMID 3470418. S2CID 32012371.
  • Welsh IR, Spitznagel JK (1973). "Distribution of lysosomal enzymes, cationic proteins, and bactericidal substances in subcellular fractions of human polymorphonuclear leukocytes". Infect. Immun. 4 (2): 97–102. doi:10.1128/IAI.4.2.97-102.1971. PMC 416271. PMID 5154881.
  • Ibrahim HR, Matsuzaki T, Aoki T (2001). "Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function". FEBS Lett. 506 (1): 27–32. doi:10.1016/S0014-5793(01)02872-1. PMID 11591365. S2CID 21593262.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Wang Z, Zhang Y, Mandal A, et al. (2005). "The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies". Clin. Cancer Res. 10 (19): 6544–50. doi:10.1158/1078-0432.CCR-04-0911. PMID 15475442.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang K, Gao R, Zhang H, et al. (2006). "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family". Biol. Reprod. 73 (5): 1064–71. doi:10.1095/biolreprod.105.041889. PMID 16014814. S2CID 21603980.


  • v
  • t
  • e