SPECC1

Protein-coding gene in the species Homo sapiens
SPECC1
Identifiers
AliasesSPECC1, CYTSB, HCMOGT-1, HCMOGT1, NSP, sperm antigen with calponin homology and coiled-coil domains 1, NSP5
External IDsOMIM: 608793; MGI: 2442356; HomoloGene: 45157; GeneCards: SPECC1; OMA:SPECC1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SPECC1
Genomic location for SPECC1
Band17p11.2Start20,008,865 bp[1]
End20,319,026 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SPECC1
Genomic location for SPECC1
Band11|11 B2Start61,847,589 bp[2]
End62,113,839 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • corpus callosum

  • C1 segment

  • sural nerve

  • testicle

  • globus pallidus

  • internal globus pallidus

  • external globus pallidus

  • substantia nigra

  • gonad
Top expressed in
  • blood

  • molar

  • motor neuron

  • fetal liver hematopoietic progenitor cell

  • lumbar subsegment of spinal cord

  • superior colliculus

  • inferior colliculus

  • cerebellar cortex

  • anterior horn of spinal cord

  • deep cerebellar nuclei
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

92521

432572

Ensembl

ENSG00000128487

ENSMUSG00000042331

UniProt

Q5M775

Q5SXY1

RefSeq (mRNA)
NM_001033553
NM_001033554
NM_001033555
NM_001243438
NM_001243439

NM_152904
NM_001386077
NM_001386078
NM_001386079
NM_001386080
NM_001386081
NM_001386082
NM_001386083
NM_001386084
NM_001386085

NM_001029936
NM_001281818
NM_001310526

RefSeq (protein)
NP_001028725
NP_001028726
NP_001028727
NP_001230367
NP_001230368

NP_690868

NP_001025107
NP_001268747
NP_001297455

Location (UCSC)Chr 17: 20.01 – 20.32 MbChr 11: 61.85 – 62.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytospin-B is a protein that, in humans, is encoded by the CYTSB gene.[5][6][7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128487 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042331 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sang N, Fath DM, Giordano A (Dec 2004). "A gene highly expressed in tumor cells encodes novel structure proteins". Oncogene. 23 (58): 9438–46. doi:10.1038/sj.onc.1207988. PMC 4518866. PMID 15602574.
  6. ^ D'Agostino L, Giordano A (Aug 2008). "Possible functional role of NSPs in cancer". Cell Cycle. 7 (12): 1810–27. doi:10.4161/cc.7.12.6023. PMID 18763323.
  7. ^ Morerio C, Acquila M, Rosanda C, Rapella A, Dufour C, Locatelli F, Maserati E, Pasquali F, Panarello C (Apr 2004). "HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)". Cancer Res. 64 (8): 2649–51. doi:10.1158/0008-5472.CAN-03-4026. PMID 15087372.
  8. ^ "Entrez Gene: SPECC1 sperm antigen with calponin homology and coiled-coil domains 1".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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