SPHK2 |
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Identifiers |
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Aliases | SPHK2, SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2 |
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External IDs | OMIM: 607092; MGI: 1861380; HomoloGene: 32456; GeneCards: SPHK2; OMA:SPHK2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 19 (human)[1] |
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| Band | 19q13.33 | Start | 48,619,291 bp[1] |
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End | 48,630,717 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 B3 | Start | 45,358,891 bp[2] |
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End | 45,367,426 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of transverse colon
- right frontal lobe
- cingulate gyrus
- anterior cingulate cortex
- prefrontal cortex
- C1 segment
- right lobe of liver
- right hemisphere of cerebellum
- Brodmann area 9
- mucosa of ileum
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| Top expressed in | - saccule
- otic placode
- aortic valve
- otic vesicle
- granulocyte
- lip
- epithelium of stomach
- duodenum
- ascending aorta
- crypt of lieberkuhn of small intestine
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - sphingosine-1-phosphate receptor activity
- transferase activity
- nucleotide binding
- kinase activity
- protein binding
- ATP binding
- D-erythro-sphingosine kinase activity
- sphinganine kinase activity
- NAD+ kinase activity
| Cellular component | - cytoplasm
- lysosome
- membrane
- lysosomal membrane
- cytosol
- intracellular membrane-bounded organelle
- nucleosome
- nucleus
- mitochondrion
- mitochondrial inner membrane
- endoplasmic reticulum
| Biological process | - phosphorylation
- sphinganine-1-phosphate biosynthetic process
- female pregnancy
- sphingosine metabolic process
- sphingosine biosynthetic process
- negative regulation of apoptotic process
- sphingolipid biosynthetic process
- brain development
- blood vessel development
- positive regulation of cell population proliferation
- cell population proliferation
- lipid phosphorylation
- sphingosine-1-phosphate receptor signaling pathway
- metabolism
- negative regulation of cell growth
- negative regulation of histone deacetylation
- positive regulation of mast cell activation involved in immune response
- positive regulation of apoptotic process
- regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of mast cell degranulation
- histone H2A-K5 acetylation
- histone H2B-K12 acetylation
- epigenetic maintenance of chromatin in transcription-competent conformation
- positive regulation of protein kinase C signaling
- positive regulation of calcium ion import
- negative regulation of histone deacetylase activity
- regulation of reactive oxygen species biosynthetic process
- cellular response to phorbol 13-acetate 12-myristate
- regulation of cytochrome-c oxidase activity
- positive regulation of ceramide biosynthetic process
- positive regulation of histone H3-K9 acetylation
- regulation of ATP biosynthetic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001204158 NM_001204159 NM_001204160 NM_001243876 NM_020126 |
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NM_001172561 NM_020011 NM_203280 |
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RefSeq (protein) | |
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NP_001191087 NP_001191088 NP_001191089 NP_001230805 NP_064511 |
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NP_001166032 NP_064395 NP_975009 |
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Location (UCSC) | Chr 19: 48.62 – 48.63 Mb | Chr 7: 45.36 – 45.37 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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