SPN1

Protein-coding gene in the species Homo sapiens
SNUPN
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1XK5, 2P8Q, 2Q5D, 2QNA, 3GB8, 3GJX, 3LWW, 3NBY, 3NBZ, 3NC0

Identifiers
AliasesSNUPN, KPNBL, RNUT1, Snurportin1, snurportin 1
External IDsOMIM: 607902; MGI: 1913319; HomoloGene: 4166; GeneCards: SNUPN; OMA:SNUPN - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SNUPN
Genomic location for SNUPN
Band15q24.2Start75,598,083 bp[1]
End75,626,469 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SNUPN
Genomic location for SNUPN
Band9|9 BStart56,858,162 bp[2]
End56,890,490 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • smooth muscle tissue

  • skeletal muscle tissue

  • muscle of thigh

  • gonad

  • gastrocnemius muscle

  • right ovary

  • left ovary

  • uterine tube
Top expressed in
  • otolith organ

  • utricle

  • primary oocyte

  • zygote

  • superior cervical ganglion

  • hand

  • morula

  • interventricular septum

  • secondary oocyte

  • seminiferous tubule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA cap binding
  • RNA binding
  • protein binding
  • nuclear import signal receptor activity
Cellular component
  • cytoplasm
  • cytosol
  • nuclear pore
  • nucleus
  • intracellular anatomical structure
Biological process
  • snRNA import into nucleus
  • protein import into nucleus
  • spliceosomal snRNP assembly
  • import into nucleus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10073

66069

Ensembl

ENSG00000169371

ENSMUSG00000055334

UniProt

O95149

Q80W37

RefSeq (mRNA)

NM_005701
NM_001042581
NM_001042588

NM_178374

RefSeq (protein)

NP_001036046
NP_001036053
NP_005692

NP_848461

Location (UCSC)Chr 15: 75.6 – 75.63 MbChr 9: 56.86 – 56.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.[5][6]

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169371 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055334 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (Sep 1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure". EMBO J. 17 (14): 4114–26. doi:10.1093/emboj/17.14.4114. PMC 1170744. PMID 9670026.
  6. ^ a b "Entrez Gene: SNUPN snurportin 1".

Further reading

  • Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm". J. Cell Biol. 145 (2): 255–64. doi:10.1083/jcb.145.2.255. PMC 2133107. PMID 10209022.
  • Narayanan U, Ospina JK, Frey MR, et al. (2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Hum. Mol. Genet. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785. PMC 1630493. PMID 12095920.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strasser A, Dickmanns A, Lührmann R, Ficner R (2005). "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1". EMBO J. 24 (13): 2235–43. doi:10.1038/sj.emboj.7600701. PMC 1173142. PMID 15920472.
  • Ospina JK, Gonsalvez GB, Bednenko J, et al. (2006). "Cross-talk between snurportin1 subdomains". Mol. Biol. Cell. 16 (10): 4660–71. doi:10.1091/mbc.E05-04-0316. PMC 1237072. PMID 16030253.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • v
  • t
  • e
  • 1xk5: Crystal structure of the m3G-cap-binding domain of snurportin1 in complex with a m3GpppG-cap dinucleotide
    1xk5: Crystal structure of the m3G-cap-binding domain of snurportin1 in complex with a m3GpppG-cap dinucleotide


Stub icon

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e