ST6GALNAC6

Protein-coding gene in the species Homo sapiens
ST6GALNAC6
Identifiers
AliasesST6GALNAC6, SIAT7-F, SIAT7F, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
External IDsOMIM: 610135; MGI: 1355316; HomoloGene: 8390; GeneCards: ST6GALNAC6; OMA:ST6GALNAC6 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for ST6GALNAC6
Genomic location for ST6GALNAC6
Band9q34.11Start127,885,321 bp[1]
End127,905,408 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ST6GALNAC6
Genomic location for ST6GALNAC6
Band2|2 BStart32,489,721 bp[2]
End32,510,818 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amygdala

  • nucleus accumbens

  • putamen

  • caudate nucleus

  • anterior cingulate cortex

  • right frontal lobe

  • hippocampus proper

  • rectum

  • right coronary artery

  • dorsolateral prefrontal cortex
Top expressed in
  • left colon

  • superior frontal gyrus

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • cerebellar cortex

  • muscle of thigh

  • right ventricle

  • olfactory tubercle

  • ciliary body
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • glycosyltransferase activity
  • sialyltransferase activity
  • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • plasma membrane
  • Golgi membrane
  • cytoplasm
Biological process
  • cell-cell recognition
  • glycoprotein metabolic process
  • glycosphingolipid metabolic process
  • protein glycosylation
  • glycosylceramide metabolic process
  • oligosaccharide metabolic process
  • sialylation
  • protein N-linked glycosylation via asparagine
  • ganglioside biosynthetic process
  • oligosaccharide biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

30815

50935

Ensembl

ENSG00000160408

ENSMUSG00000026811

UniProt

Q969X2

Q9JM95

RefSeq (mRNA)
NM_001286999
NM_001287000
NM_001287001
NM_001287002
NM_001287003

NM_013443
NM_001388489

NM_001025310
NM_001025311
NM_001289547
NM_001289548
NM_001289549

NM_016973

RefSeq (protein)
NP_001273928
NP_001273929
NP_001273930
NP_001273931
NP_001273932

NP_038471

NP_001020481
NP_001020482
NP_001276476
NP_001276477
NP_001276478

NP_058669

Location (UCSC)Chr 9: 127.89 – 127.91 MbChr 2: 32.49 – 32.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160408 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026811 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.
  6. ^ "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

Further reading

  • Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC 1863573. PMID 17123352.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi:10.1093/glycob/cwi063. PMID 15843597.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi:10.1074/jbc.275.10.6717. PMID 10702226.


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