STAP2

Protein-coding gene in the species Homo sapiens

STAP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EL8

Identifiers
AliasesSTAP2, BKS, signal transducing adaptor family member 2
External IDsOMIM: 607881; MGI: 2147039; HomoloGene: 9798; GeneCards: STAP2; OMA:STAP2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for STAP2
Genomic location for STAP2
Band19p13.3Start4,324,043 bp[1]
End4,342,786 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for STAP2
Genomic location for STAP2
Band17|17 DStart56,304,077 bp[2]
End56,312,584 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • mucosa of ileum

  • skin of abdomen

  • skin of leg

  • rectum

  • olfactory zone of nasal mucosa

  • mucosa of sigmoid colon

  • pancreatic ductal cell

  • right lobe of liver

  • minor salivary glands
Top expressed in
  • intestinal villus

  • jejunum

  • ileum

  • duodenum

  • parotid gland

  • epithelium of small intestine

  • large intestine

  • colon

  • crypt of lieberkuhn of small intestine

  • submandibular gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • signaling adaptor activity
Cellular component
  • cytoplasm
  • cytosol
  • plasma membrane
Biological process
  • positive regulation of tyrosine phosphorylation of STAT protein
  • positive regulation of signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55620

106766

Ensembl

ENSG00000178078

ENSMUSG00000038781

UniProt

Q9UGK3

Q8R0L1

RefSeq (mRNA)

NM_001013841
NM_017720

NM_145934

RefSeq (protein)

NP_001013863
NP_060190

NP_666046

Location (UCSC)Chr 19: 4.32 – 4.34 MbChr 17: 56.3 – 56.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.[5][6][7]

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.[7]

Interactions

STAP2 has been shown to interact with PTK6.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178078 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038781 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Mitchell PJ, Sara EA, Crompton MR (Oct 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. PMID 10980601. S2CID 10682133.
  6. ^ Dehal P, Predki P, Olsen AS, Kobayashi A, Folta P, Lucas S, Land M, Terry A, Ecale Zhou CL, Rash S, Zhang Q, Gordon L, Kim J, Elkin C, Pollard MJ, Richardson P, Rokhsar D, Uberbacher E, Hawkins T, Branscomb E, Stubbs L (Jul 2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
  7. ^ a b "Entrez Gene: STAP2 signal-transducing adaptor protein-2".

Further reading

  • Rosenzweig BL, Imamura T, Okadome T, et al. (1995). "Cloning and characterization of a human type II receptor for bone morphogenetic proteins". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7632–6. Bibcode:1995PNAS...92.7632R. doi:10.1073/pnas.92.17.7632. PMC 41199. PMID 7644468.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Minoguchi M, Minoguchi S, Aki D, et al. (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem. 278 (13): 11182–9. doi:10.1074/jbc.M211230200. PMID 12540842.
  • Yamamoto T, Yumioka T, Sekine Y, et al. (2003). "Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells". Biochem. Biophys. Res. Commun. 306 (3): 767–73. doi:10.1016/S0006-291X(03)01042-8. PMID 12810085.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sekine Y, Yamamoto T, Yumioka T, et al. (2005). "Physical and functional interactions between STAP-2/BKS and STAT5". J. Biol. Chem. 280 (9): 8188–96. doi:10.1074/jbc.M411692200. hdl:2115/28113. PMID 15611091.
  • Sekine Y, Tsuji S, Ikeda O, et al. (2007). "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase". J. Immunol. 179 (4): 2397–407. doi:10.4049/jimmunol.179.4.2397. PMID 17675501.


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