STEAP1

Protein-coding gene in the species Homo sapiens
STEAP1
Identifiers
AliasesSTEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDsOMIM: 604415; MGI: 1917608; HomoloGene: 8256; GeneCards: STEAP1; OMA:STEAP1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for STEAP1
Genomic location for STEAP1
Band7q21.13Start90,154,456 bp[1]
End90,164,829 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for STEAP1
Genomic location for STEAP1
Band5 A1|5 3.2 cMStart5,786,317 bp[2]
End5,799,326 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pericardium

  • cartilage tissue

  • prostate

  • tendon of biceps brachii

  • Achilles tendon

  • parietal pleura

  • gonad

  • mucosa of transverse colon

  • abdominal fat

  • gallbladder
Top expressed in
  • Epithelium of choroid plexus

  • endothelial cell of lymphatic vessel

  • lumbar spinal ganglion

  • epithelium of lens

  • molar

  • hair follicle

  • yolk sac

  • adrenal gland

  • Paneth cell

  • iris
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ferric-chelate reductase (NADPH) activity
  • metal ion binding
  • transporter activity
  • oxidoreductase activity
  • cupric reductase activity
  • channel activity
Cellular component
  • endosome membrane
  • integral component of membrane
  • cell-cell junction
  • integral component of plasma membrane
  • membrane
  • endosome
  • plasma membrane
Biological process
  • ion transport
  • copper ion import
  • iron ion homeostasis
  • transmembrane transport
  • iron ion import across cell outer membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26872

70358

Ensembl

ENSG00000164647

ENSMUSG00000015652

UniProt

Q9UHE8

Q9CWR7

RefSeq (mRNA)

NM_012449

NM_027399

RefSeq (protein)

NP_036581

NP_081675

Location (UCSC)Chr 7: 90.15 – 90.16 MbChr 5: 5.79 – 5.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.[5]

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164647 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015652 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".

Further reading

  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Hubert RS, Vivanco I, Chen E, et al. (2000). "STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors". Proc. Natl. Acad. Sci. U.S.A. 96 (25): 14523–8. doi:10.1073/pnas.96.25.14523. PMC 24469. PMID 10588738.
  • Yang D, Holt GE, Velders MP, et al. (2001). "Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice". Cancer Res. 61 (15): 5857–60. PMID 11479226.
  • Korkmaz KS, Elbi C, Korkmaz CG, et al. (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J. Biol. Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rodeberg DA, Nuss RA, Elsawa SF, Celis E (2005). "Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes". Clin. Cancer Res. 11 (12): 4545–52. doi:10.1158/1078-0432.CCR-04-2235. PMC 1698136. PMID 15958640.


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