SV2B

Protein-coding gene in the species Homo sapiens
SV2B
Identifiers
AliasesSV2B, HsT19680, synaptic vesicle glycoprotein 2B
External IDsOMIM: 185861; MGI: 1927338; HomoloGene: 32236; GeneCards: SV2B; OMA:SV2B - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SV2B
Genomic location for SV2B
Band15q26.1Start91,099,950 bp[1]
End91,302,565 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SV2B
Genomic location for SV2B
Band7|7 D1Start74,764,642 bp[2]
End74,959,010 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • Brodmann area 10

  • Brodmann area 23

  • frontal pole

  • Brodmann area 46

  • orbitofrontal cortex

  • paraflocculus of cerebellum

  • superior frontal gyrus

  • pons

  • postcentral gyrus
Top expressed in
  • subiculum

  • piriform cortex

  • prefrontal cortex

  • primary motor cortex

  • dentate gyrus of hippocampal formation granule cell

  • temporal lobe

  • amygdala

  • cingulate gyrus

  • hippocampus proper

  • superior frontal gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • transmembrane transporter activity
  • transporter activity
Cellular component
  • cell junction
  • plasma membrane
  • synapse
  • acrosomal vesicle
  • membrane
  • cytoplasmic vesicle
  • synaptic vesicle
  • integral component of membrane
  • synaptic vesicle membrane
  • neuron projection
Biological process
  • neurotransmitter transport
  • transmembrane transport
  • chemical synaptic transmission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9899

64176

Ensembl

ENSG00000185518

ENSMUSG00000053025

UniProt

Q7L1I2

Q8BG39

RefSeq (mRNA)
NM_001167580
NM_014848
NM_001323031
NM_001323032
NM_001323033

NM_001323034
NM_001323036
NM_001323037
NM_001323038
NM_001323039
NM_001323040

NM_001109753
NM_153579
NM_001360571
NM_001360572
NM_001360573

NM_001360574
NM_001360575

RefSeq (protein)
NP_001161052
NP_001309960
NP_001309961
NP_001309962
NP_001309963

NP_001309965
NP_001309966
NP_001309967
NP_001309968
NP_001309969
NP_055663

NP_001103223
NP_705807
NP_001347500
NP_001347501
NP_001347502

NP_001347503
NP_001347504

Location (UCSC)Chr 15: 91.1 – 91.3 MbChr 7: 74.76 – 74.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptic vesicle glycoprotein 2B is a protein that in humans is encoded by the SV2B gene.[5][6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185518 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053025 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ Bajjalieh SM, Peterson K, Linial M, Scheller RH (Apr 1993). "Brain contains two forms of synaptic vesicle protein 2". Proc Natl Acad Sci U S A. 90 (6): 2150–4. Bibcode:1993PNAS...90.2150B. doi:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585.
  7. ^ "Entrez Gene: SV2B synaptic vesicle glycoprotein 2B".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lazzell DR, Belizaire R, Thakur P, et al. (2005). "SV2B regulates synaptotagmin 1 by direct interaction". J. Biol. Chem. 279 (50): 52124–31. doi:10.1074/jbc.M407502200. PMID 15466855.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Janz R, Goda Y, Geppert M, et al. (2000). "SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release". Neuron. 24 (4): 1003–16. doi:10.1016/S0896-6273(00)81046-6. PMID 10624962.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
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