Group of protein families
The sex hormone receptors, or sex steroid receptors, are a group of steroid hormone receptors that interact with the sex hormones, the androgens, estrogens, and progestogens, as well as with sex-hormonal agents such as anabolic steroids, progestins, and antiestrogens. They include the:
- Androgen receptor (AR) (A, B) - binds and is activated by androgens such as testosterone and dihydrotestosterone (DHT)
- Estrogen receptor (ER) (α, β) - binds and is activated by estrogens such as estradiol, estrone, and estriol
- Progesterone receptor (PR) (A, B) - binds and is activated by progestogens such as progesterone
In addition, sex steroids have been found to bind and activate membrane steroid receptors, such as estradiol and GPER.
See also
References
(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
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Amino acids and similar/related | - Amino acids and related: GABA receptor modulators
- GABAA receptor positive modulators
- GABA metabolism and transport modulators
- GHB receptor modulators
- Glutamate metabolism and transport modulators
- Glycine receptor modulators
- Ionotropic glutamate receptor modulators
- Metabotropic glutamate receptor modulators
- Monoamines: Adrenergic receptor modulators
- Dopamine receptor modulators
- Histamine receptor modulators
- Melatonin receptor modulators
- Monoamine metabolism modulators
- Monoamine neurotoxins
- Monoamine releasing agents
- Monoamine reuptake inhibitors
- Serotonin receptor modulators
- hTAAR modulators
- Acetylcholine: Acetylcholine metabolism and transport modulators
- Muscarinic acetylcholine receptor modulators
- Nicotinic acetylcholine receptor modulators
- Others: Imidazoline receptor modulators
- Purine receptor modulators
- Sigma receptor modulators
- Thyroid hormone receptor modulators
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Lipids | - Eicosanoids: Cannabinoid receptor modulators
- Leukotriene signaling modulators
- Prostanoid signaling modulators
- Phospholipids: Lysophospholipid signaling modulators
- PAF receptor modulators
- Steroids: Androgen receptor modulators
- Estrogen receptor modulators
- Glucocorticoid receptor modulators
- Mineralocorticoid receptor modulators
- Progesterone receptor modulators
- Steroid metabolism modulators
- Other nuclear receptors: Aryl hydrocarbon receptor modulators
- Estrogen-related receptor modulators
- FXR and LXR modulators
- PPAR modulators
- Retinoid receptor modulators
- Vitamin D receptor modulators
- Xenobiotic-sensing receptor modulators
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Peptides/proteins | - Peptides: Angiotensin receptor modulators
- GH/IGF-1 axis signaling modulators
- GnRH and gonadotropin receptor modulators
- Melanocortin receptor modulators
- Neurokinin receptor modulators
- Opioid receptor modulators
- Oxytocin and vasopressin receptor modulators
- Cytokines: Cytokine receptor modulators
- Chemokine receptor modulators
- Interleukin receptor modulators
- TNF receptor superfamily modulators
- Growth factors: Growth factor receptor modulators
- TGFβ receptor superfamily modulators
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Others and non-receptor | - Ion channels: Ion channel modulators
- TRP channel modulators
- Transporters: Sodium-glucose transporter modulators
- Symporter inhibitors
- Others: Nitric oxide signaling modulators
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