TAC4

Protein-coding gene in the species Homo sapiens
TAC4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2MOC

Identifiers
AliasesTAC4, EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4
External IDsOMIM: 607833; MGI: 1931130; HomoloGene: 89219; GeneCards: TAC4; OMA:TAC4 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TAC4
Genomic location for TAC4
Band17q21.33Start49,838,300 bp[1]
End49,848,069 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TAC4
Genomic location for TAC4
Band11|11 DStart95,152,355 bp[2]
End95,160,091 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • buccal mucosa cell

  • myocardium

  • granulocyte

  • vena cava

  • cerebellar vermis

  • anterior pituitary

  • right lobe of thyroid gland

  • blood

  • left lobe of thyroid gland
Top expressed in
  • lip

  • pineal gland

  • olfactory epithelium

  • tibiofemoral joint

  • right ventricle

  • skin of abdomen

  • lumbar spinal ganglion

  • aortic valve

  • granulocyte

  • medial ganglionic eminence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • signaling receptor binding
  • substance P receptor binding
  • substance K receptor binding
  • receptor ligand activity
Cellular component
  • extracellular region
  • extracellular space
Biological process
  • regulation of blood pressure
  • inflammatory response
  • cell-cell signaling
  • negative regulation of systemic arterial blood pressure
  • tachykinin receptor signaling pathway
  • regulation of signaling receptor activity
  • detection of temperature stimulus involved in sensory perception of pain
  • regulation of sensory perception of pain
  • positive regulation of flagellated sperm motility
  • negative regulation of sensory perception of pain
  • positive regulation of sensory perception of pain
  • positive regulation of cytosolic calcium ion concentration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

255061

93670

Ensembl

ENSG00000176358

ENSMUSG00000020872

UniProt

Q86UU9

Q99N14

RefSeq (mRNA)

NM_170685
NM_001077503
NM_001077504
NM_001077505
NM_001077506

NM_053093

RefSeq (protein)

NP_001070971
NP_001070972
NP_001070973
NP_001070974
NP_733786

NP_444323

Location (UCSC)Chr 17: 49.84 – 49.85 MbChr 11: 95.15 – 95.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.[5][6][7]

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176358 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020872 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ (Mar 2001). "Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis". Nat Immunol. 1 (5): 392–7. doi:10.1038/80826. PMID 11062498. S2CID 24408728.
  6. ^ Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q (Oct 2002). "Identification, localization and receptor characterization of novel mammalian substance P-like peptides". Gene. 296 (1–2): 205–12. doi:10.1016/S0378-1119(02)00861-2. PMID 12383518.
  7. ^ a b "Entrez Gene: TAC4 tachykinin 4 (hemokinin)".

Further reading

  • Page NM (2007). "Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides". Vascul. Pharmacol. 45 (4): 200–8. doi:10.1016/j.vph.2005.08.028. PMID 16931167.
  • Page NM (2004). "Hemokinins and endokinins". Cell. Mol. Life Sci. 61 (13): 1652–63. doi:10.1007/s00018-004-4035-x. PMC 11138928. PMID 15224188. S2CID 31599641.
  • Cunningham S, O'Doherty C, Patterson C, et al. (2007). "The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis" (PDF). J. Neuroimmunol. 183 (1–2): 208–13. doi:10.1016/j.jneuroim.2006.11.002. PMID 17175032. S2CID 23701000.
  • Page NM, Bell NJ, Gardiner SM, et al. (2003). "Characterization of the endokinins: Human tachykinins with cardiovascular activity". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6245–50. Bibcode:2003PNAS..100.6245P. doi:10.1073/pnas.0931458100. PMC 156357. PMID 12716968.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bellucci F, Carini F, Catalani C, et al. (2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1". Br. J. Pharmacol. 135 (1): 266–74. doi:10.1038/sj.bjp.0704443. PMC 1573107. PMID 11786503.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Overview of all the structural information available in the PDB for UniProt: Q86UU9 (Tachykinin-4) at the PDBe-KB.
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