TFPT

Protein-coding gene in the species Homo sapiens
TFPT
Identifiers
AliasesTFPT, FB1, INO80F, amida, TCF3 (E2A) fusion partner (in childhood Leukemia), TCF3 fusion partner
External IDsOMIM: 609519; MGI: 1916964; HomoloGene: 8349; GeneCards: TFPT; OMA:TFPT - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for TFPT
Genomic location for TFPT
Band19q13.42Start54,107,020 bp[1]
End54,115,657 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for TFPT
Genomic location for TFPT
Band7|7 A1Start3,623,323 bp[2]
End3,632,928 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amygdala

  • prefrontal cortex

  • anterior cingulate cortex

  • hippocampus proper

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • right frontal lobe

  • substantia nigra

  • putamen

  • hypothalamus
Top expressed in
  • aortic valve

  • ascending aorta

  • supraoptic nucleus

  • primary oocyte

  • fossa

  • internal carotid artery

  • condyle

  • yolk sac

  • motor neuron

  • hair follicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
Cellular component
  • cytoplasm
  • nuclear membrane
  • Ino80 complex
  • nucleus
  • nucleoplasm
Biological process
  • apoptotic signaling pathway
  • apoptotic process
  • DNA recombination
  • regulation of transcription, DNA-templated
  • DNA repair
  • transcription, DNA-templated
  • cellular response to DNA damage stimulus
  • protein deubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29844

69714

Ensembl
ENSG00000275086
ENSG00000276504
ENSG00000274073
ENSG00000276022
ENSG00000276263

ENSG00000278161
ENSG00000105619
ENSG00000276296
ENSG00000276323
ENSG00000273833

ENSMUSG00000006335

UniProt

P0C1Z6

Q3U1J1

RefSeq (mRNA)

NM_013342
NM_001321792

NM_001290381
NM_023524

RefSeq (protein)

NP_001308721
NP_037474
NP_001308721.1

NP_001277310
NP_076013

Location (UCSC)Chr 19: 54.11 – 54.12 MbChr 7: 3.62 – 3.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TCF3 fusion partner is a protein that in humans is encoded by the TFPT gene.[5][6][7]

References

  1. ^ a b c ENSG00000276504, ENSG00000274073, ENSG00000276022, ENSG00000276263, ENSG00000278161, ENSG00000105619, ENSG00000276296, ENSG00000276323, ENSG00000273833 GRCh38: Ensembl release 89: ENSG00000275086, ENSG00000276504, ENSG00000274073, ENSG00000276022, ENSG00000276263, ENSG00000278161, ENSG00000105619, ENSG00000276296, ENSG00000276323, ENSG00000273833 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006335 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Irie Y, Yamagata K, Gan Y, Miyamoto K, Do E, Kuo CH, Taira E, Miki N (Feb 2000). "Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells". J Biol Chem. 275 (4): 2647–2653. doi:10.1074/jbc.275.4.2647. PMID 10644725.
  6. ^ Jin J, Cai Y, Yao T, Gottschalk AJ, Florens L, Swanson SK, Gutierrez JL, Coleman MK, Workman JL, Mushegian A, Washburn MP, Conaway RC, Conaway JW (Dec 2005). "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex". J Biol Chem. 280 (50): 41207–41212. doi:10.1074/jbc.M509128200. PMID 16230350.
  7. ^ "Entrez Gene: TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)".

Further reading

  • Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–272. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Franchini C, Fontana F, Minuzzo M, et al. (2007). "Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced". Apoptosis. 11 (12): 2217–2224. doi:10.1007/s10495-006-0195-5. PMID 17041757. S2CID 37448238.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brambillasca F, Mosna G, Colombo M, et al. (1999). "Identification of a novel molecular partner of the E2A gene in childhood leukemia". Leukemia. 13 (3): 369–375. doi:10.1038/sj/leu/2401338. PMID 10086727.


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