TIMM17A

Protein-coding gene in the species Homo sapiens
TIMM17A
Identifiers
AliasesTIMM17A, TIM17, TIM17A, translocase of inner mitochondrial membrane 17 homolog A (yeast), translocase of inner mitochondrial membrane 17A
External IDsOMIM: 605057; MGI: 1343131; HomoloGene: 115910; GeneCards: TIMM17A; OMA:TIMM17A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TIMM17A
Genomic location for TIMM17A
Band1q32.1Start201,955,503 bp[1]
End201,970,664 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for TIMM17A
Genomic location for TIMM17A
Band1|1 E4Start135,295,213 bp[2]
End135,313,778 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • right ventricle

  • biceps brachii

  • middle temporal gyrus

  • endothelial cell

  • orbitofrontal cortex

  • amniotic fluid

  • Skeletal muscle tissue of biceps brachii

  • myocardium of left ventricle

  • Epithelium of choroid plexus
Top expressed in
  • morula

  • morula

  • interventricular septum

  • soleus muscle

  • blastocyst

  • extraocular muscle

  • temporal muscle

  • cardiac muscle tissue of left ventricle

  • masseter muscle

  • plantaris muscle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein-transporting ATPase activity
  • protein transmembrane transporter activity
Cellular component
  • nucleoplasm
  • integral component of mitochondrial inner membrane
  • mitochondrial inner membrane
  • integral component of membrane
  • TIM23 mitochondrial import inner membrane translocase complex
  • mitochondrion
  • membrane
Biological process
  • protein targeting to mitochondrion
  • protein import into mitochondrial matrix
  • protein transport
  • intracellular protein transport
  • positive regulation of protein processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10440

21854

Ensembl

ENSG00000134375

ENSMUSG00000062580

UniProt

Q99595

Q9Z0V8

RefSeq (mRNA)

NM_006335

NM_011590

RefSeq (protein)

NP_006326

NP_035720
NP_001347786
NP_001347787

Location (UCSC)Chr 1: 201.96 – 201.97 MbChr 1: 135.3 – 135.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene.[5][6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134375 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062580 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bomer U, Rassow J, Zufall N, Pfanner N, Meijer M, Maarse AC (Dec 1996). "The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17". J Mol Biol. 262 (4): 389–395. doi:10.1006/jmbi.1996.0522. PMID 8893850.
  6. ^ Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID 10339406.
  7. ^ "Entrez Gene: TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Piesse C, Tymms M, Garrafa E, et al. (2002). "Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression". Gene. 292 (1–2): 129–140. doi:10.1016/S0378-1119(02)00650-9. PMID 12119107.
  • Moro F, Sirrenberg C, Schneider HC, et al. (1999). "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix". EMBO J. 18 (13): 3667–3675. doi:10.1093/emboj/18.13.3667. PMC 1171444. PMID 10393182.
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