TMIGD1

Protein-coding gene in the species Homo sapiens
TMIGD1
Identifiers
AliasesTMIGD1, TMIGD, UNQ9372, transmembrane and immunoglobulin domain containing 1
External IDsMGI: 1913851; HomoloGene: 41641; GeneCards: TMIGD1; OMA:TMIGD1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TMIGD1
Genomic location for TMIGD1
Band17q11.2Start30,316,333 bp[1]
End30,334,059 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TMIGD1
Genomic location for TMIGD1
Band11|11 B5Start76,792,985 bp[2]
End76,807,413 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • rectum

  • mucosa of transverse colon

  • epithelium of colon

  • human kidney

  • smooth muscle tissue

  • duodenum

  • appendix

  • renal cortex

  • muscle layer of sigmoid colon

  • lymph node
Top expressed in
  • intestinal villus

  • right kidney

  • human kidney

  • ileum

  • Paneth cell

  • proximal tubule

  • jejunum

  • esophagus

  • submandibular gland

  • epithelium of small intestine
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

388364

66601

Ensembl

ENSG00000182271

ENSMUSG00000020839

UniProt

Q6UXZ0

Q9D7L8

RefSeq (mRNA)

NM_206832
NM_001319942

NM_025655
NM_001382246
NM_001382247

RefSeq (protein)

NP_001306871
NP_996663

NP_079931
NP_001369175
NP_001369176

Location (UCSC)Chr 17: 30.32 – 30.33 MbChr 11: 76.79 – 76.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene.[5] TMIGD1 was discovered by the lab of Giancarlo Marra[6] and later cloned by Nader Rahimi.[7][8] Recent findings suggest functions in brush border formation (intestinal epithelium) and roles as tumor suppressor (kidney and intestine).[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182271 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020839 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Transmembrane and immunoglobulin domain containing 1". Retrieved 2017-02-20.
  6. ^ Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, et al. (May 2011). "Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)". EMBO Mol Med. 3 (6): 334–347. doi:10.1002/emmm.201100141. PMC 5839393. PMID 3377079.
  7. ^ Meyer RD, Zou X, Ali M, Ersoy E, Bondzie PA, Lavaei M, et al. (February 2018). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget.23822. PMC 5839393. PMID 29515762.
  8. ^ Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, et al. (October 2015). "TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury". The American Journal of Pathology. 185 (10): 2757–67. doi:10.1016/j.ajpath.2015.06.006. PMC 4607757. PMID 26342724.
  9. ^ Thuering E, et al. (April 2023). "TMIGD1: Emerging functions of a tumor suppressor and adhesion receptor". Oncogene. 42 (22): 1777–1785. doi:10.1038/s41388-023-02696-5. PMC 10238269. PMID 37087524.
  • v
  • t
  • e