TOM1L2

Protein-coding gene in the species Homo sapiens
TOM1L2
Identifiers
AliasesTOM1L2, target of myb1 like 2 membrane trafficking protein
External IDsOMIM: 615519; MGI: 2443306; HomoloGene: 44901; GeneCards: TOM1L2; OMA:TOM1L2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TOM1L2
Genomic location for TOM1L2
Band17p11.2Start17,843,511 bp[1]
End17,972,422 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TOM1L2
Genomic location for TOM1L2
Band11|11 B2Start60,117,540 bp[2]
End60,243,731 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • apex of heart

  • right auricle

  • left ventricle

  • right frontal lobe

  • right lobe of thyroid gland

  • lateral nuclear group of thalamus

  • skin of leg

  • amygdala

  • right hemisphere of cerebellum
Top expressed in
  • habenula

  • pontine nuclei

  • superior colliculus

  • dorsal tegmental nucleus

  • central gray substance of midbrain

  • dentate gyrus of hippocampal formation granule cell

  • subiculum

  • ventral tegmental area

  • primary visual cortex

  • superior frontal gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • clathrin binding
  • protein binding
  • protein kinase binding
Cellular component
  • extracellular exosome
  • intracellular anatomical structure
Biological process
  • protein transport
  • intracellular protein transport
  • negative regulation of mitotic nuclear division
  • signal transduction
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

146691

216810

Ensembl

ENSG00000175662

ENSMUSG00000000538

UniProt

Q6ZVM7

Q5SRX1

RefSeq (mRNA)
NM_001033551
NM_001082968
NM_001288786
NM_001288787
NM_001288788

NM_001288789
NM_144678
NM_001350331
NM_001350332
NM_001350333

NM_001039092
NM_001039093
NM_153080
NM_001359810

RefSeq (protein)
NP_001028723
NP_001076437
NP_001275715
NP_001275716
NP_001275717

NP_001275718
NP_001337260
NP_001337261
NP_001337262

NP_001034181
NP_001034182
NP_694720
NP_001346739
NP_001390817

NP_001390820
NP_001390822
NP_001390824
NP_001390825

Location (UCSC)Chr 17: 17.84 – 17.97 MbChr 11: 60.12 – 60.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TOM1-like protein 2 is a protein that in humans is encoded by the TOM1L2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175662 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000538 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seranski P, Heiss NS, Dhorne-Pollet S, Radelof U, Korn B, Hennig S, Backes E, Schmidt S, Wiemann S, Schwarz CE, Lehrach H, Poustka A (May 1999). "Transcription mapping in a medulloblastoma breakpoint interval and Smith-Magenis syndrome candidate region: identification of 53 transcriptional units and new candidate genes". Genomics. 56 (1): 1–11. doi:10.1006/geno.1998.5647. PMID 10036180.
  6. ^ "Entrez Gene: TOM1L2 target of myb1-like 2 (chicken)".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Katoh Y, Imakagura H, Futatsumori M, Nakayama K (2006). "Recruitment of clathrin onto endosomes by the Tom1-Tollip complex". Biochem. Biophys. Res. Commun. 341 (1): 143–9. doi:10.1016/j.bbrc.2005.12.156. PMID 16412388.
  • Franco M, Furstoss O, Simon V, et al. (2006). "The Adaptor Protein Tom1L1 Is a Negative Regulator of Src Mitogenic Signaling Induced by Growth Factors". Mol. Cell. Biol. 26 (5): 1932–47. doi:10.1128/MCB.26.5.1932-1947.2006. PMC 1430241. PMID 16479011.


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