TRIM15

Protein-coding gene in the species Homo sapiens
TRIM15
Identifiers
AliasesTRIM15, RNF93, ZNF178, ZNFB7, tripartite motif containing 15
External IDsMGI: 1916347; HomoloGene: 23819; GeneCards: TRIM15; OMA:TRIM15 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TRIM15
Genomic location for TRIM15
Band6p22.1Start30,163,206 bp[1]
End30,172,693 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for TRIM15
Genomic location for TRIM15
Band17|17 B1Start37,171,583 bp[2]
End37,178,102 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • duodenum

  • mucosa of transverse colon

  • rectum

  • right lobe of liver

  • gallbladder

  • human kidney

  • appendix

  • epithelium of colon

  • smooth muscle tissue

  • islet of Langerhans
Top expressed in
  • intestinal villus

  • ileum

  • jejunum

  • primary oocyte

  • epithelium of small intestine

  • duodenum

  • secondary oocyte

  • zygote

  • yolk sac

  • embryo
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • metal ion binding
Cellular component
  • intracellular anatomical structure
Biological process
  • mesodermal cell fate determination
  • positive regulation of DNA-binding transcription factor activity
  • innate immune response
  • positive regulation of RIG-I signaling pathway
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of type I interferon production
  • negative regulation of intracellular transport of viral material
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89870

69097

Ensembl
ENSG00000235960
ENSG00000227147
ENSG00000233599
ENSG00000204610
ENSG00000224145

ENSG00000235905
ENSG00000137384
ENSG00000235259

ENSMUSG00000050747

UniProt

Q9C019

n/a

RefSeq (mRNA)

NM_033229
NM_052812

NM_001024134
NM_001177872

RefSeq (protein)

NP_150232

n/a

Location (UCSC)Chr 6: 30.16 – 30.17 MbChr 17: 37.17 – 37.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.[5][6][7][8]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[8]

References

  1. ^ a b c ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 GRCh38: Ensembl release 89: ENSG00000235960, ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050747 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. ^ Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR (Mar 1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection". Am J Hum Genet. 54 (2): 244–51. PMC 1918154. PMID 8304341.
  7. ^ Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM (Feb 1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.
  8. ^ a b "Entrez Gene: TRIM15 tripartite motif-containing 15".

Further reading

  • Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Harada H, Harada Y, O'Brien DP, et al. (1999). "HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells". Mol. Cell. Biol. 19 (5): 3808–15. doi:10.1128/MCB.19.5.3808. PMC 84222. PMID 10207104.