TRIP4

Protein-coding gene in the species Homo sapiens

TRIP4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2E5O

Identifiers
AliasesTRIP4, ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
External IDsOMIM: 604501; MGI: 1928469; HomoloGene: 9426; GeneCards: TRIP4; OMA:TRIP4 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for TRIP4
Genomic location for TRIP4
Band15q22.31Start64,387,748 bp[1]
End64,455,303 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for TRIP4
Genomic location for TRIP4
Band9|9 CStart65,736,212 bp[2]
End65,816,076 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • amniotic fluid

  • mucosa of transverse colon

  • jejunal mucosa

  • monocyte

  • gonad

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • ganglionic eminence

  • anterior pituitary
Top expressed in
  • pineal gland

  • granulocyte

  • spermatocyte

  • left lobe of liver

  • zygote

  • spermatid

  • lumbar spinal ganglion

  • secondary oocyte

  • substantia nigra

  • cumulus cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protease binding
  • transcription coactivator activity
  • zinc ion binding
  • estrogen receptor binding
  • protein binding
  • histone acetyltransferase binding
  • nuclear receptor binding
  • ubiquitin-like protein ligase binding
  • metal ion binding
  • protein kinase binding
Cellular component
  • cytoplasm
  • cytosol
  • cytoskeleton
  • nucleus
  • nucleoplasm
  • microtubule organizing center
  • neuromuscular junction
  • nuclear body
  • activating signal cointegrator 1 complex
  • centrosome
  • protein-containing complex
Biological process
  • positive regulation of transcription, DNA-templated
  • toxin transport
  • intracellular estrogen receptor signaling pathway
  • transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • regulation of myoblast differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9325

56404

Ensembl

ENSG00000103671

ENSMUSG00000032386

UniProt

Q15650

Q9QXN3

RefSeq (mRNA)

NM_016213
NM_001321924

NM_001170907
NM_019797
NM_001357872

RefSeq (protein)

NP_001308853
NP_057297

NP_001164378
NP_062771
NP_001344801

Location (UCSC)Chr 15: 64.39 – 64.46 MbChr 9: 65.74 – 65.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.[5][6]

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103671 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032386 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
  6. ^ "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
  7. ^ Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
  • Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
  • Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.


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