TXNL1

Protein-coding gene in the species Homo sapiens
TXNL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1GH2, 1WWY

Identifiers
AliasesTXNL1, HEL-S-114, TRP32, TXL-1, TXNL, Txl, thioredoxin like 1
External IDsOMIM: 603049; MGI: 1860078; HomoloGene: 3515; GeneCards: TXNL1; OMA:TXNL1 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for TXNL1
Genomic location for TXNL1
Band18q21.31Start56,597,209 bp[1]
End56,651,600 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for TXNL1
Genomic location for TXNL1
Band18|18 E1Start63,794,165 bp[2]
End63,841,872 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • endothelial cell

  • hair follicle

  • oral cavity

  • right ventricle

  • trabecular bone

  • biceps brachii

  • retinal pigment epithelium

  • Epithelium of choroid plexus

  • middle temporal gyrus
Top expressed in
  • endocardial cushion

  • atrioventricular valve

  • Paneth cell

  • fossa

  • condyle

  • abdominal wall

  • facial motor nucleus

  • lacrimal gland

  • dermis

  • vas deferens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • disulfide oxidoreductase activity
  • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
  • thioredoxin-disulfide reductase activity
  • protein-disulfide reductase activity
  • protein-disulfide reductase (NAD(P)) activity
Cellular component
  • cytoplasm
  • proteasome complex
  • nucleus
  • cytosol
Biological process
  • cellular response to oxidative stress
  • cell redox homeostasis
  • cellular oxidant detoxification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9352

53382

Ensembl

ENSG00000091164

ENSMUSG00000024583

UniProt

O43396

Q8CDN6

RefSeq (mRNA)

NM_004786

NM_016792

RefSeq (protein)

NP_004777

NP_058072

Location (UCSC)Chr 18: 56.6 – 56.65 MbChr 18: 63.79 – 63.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thioredoxin-like protein 1 is a protein that in humans is encoded by the TXNL1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091164 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024583 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miranda-Vizuete A, Gustafsson JA, Spyrou G (Mar 1998). "Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein". Biochem Biophys Res Commun. 243 (1): 284–288. doi:10.1006/bbrc.1997.8003. PMID 9473519.
  6. ^ Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K, Yonehara S (Aug 1998). "Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa". J Biol Chem. 273 (30): 19160–19166. doi:10.1074/jbc.273.30.19160. PMID 9668102.
  7. ^ "Entrez Gene: TXNL1 thioredoxin-like 1".

Further reading

  • Miranda-Vizuete A, Spyrou G (2000). "Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl)". DNA Seq. 10 (6): 419–24. doi:10.3109/10425170009015613. hdl:10261/47456. PMID 10826702. S2CID 38627981.
  • Jin J, Chen X, Zhou Y, et al. (2002). "Crystal structure of the catalytic domain of a human thioredoxin-like protein". Eur. J. Biochem. 269 (8): 2060–2068. doi:10.1046/j.1432-1033.2002.02844.x. PMID 11985582.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kim KY, Lee JW, Park MS, et al. (2006). "Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2)". Int. J. Cancer. 118 (7): 1670–1679. doi:10.1002/ijc.21572. PMID 16231315. S2CID 21916723.
  • Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–1318. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
  • Jiménez A, Pelto-Huikko M, Gustafsson JA, Miranda-Vizuete A (2006). "Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation". FEBS Lett. 580 (3): 960–967. doi:10.1016/j.febslet.2006.01.025. hdl:10261/46508. PMID 16438969. S2CID 18655983.
  • v
  • t
  • e
  • 1gh2: Crystal structure of the catalytic domain of a new human thioredoxin-like protein
    1gh2: Crystal structure of the catalytic domain of a new human thioredoxin-like protein
  • 1wwy: Solution structure of the DUF1000 domain of a thioredoxin-like protein 1
    1wwy: Solution structure of the DUF1000 domain of a thioredoxin-like protein 1


Stub icon

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e