Tektin-1

Protein-coding gene in the species Homo sapiens
TEKT1
Identifiers
AliasesTEKT1, tektin 1
External IDsOMIM: 609002; MGI: 1333819; HomoloGene: 7973; GeneCards: TEKT1; OMA:TEKT1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TEKT1
Genomic location for TEKT1
Band17p13.1Start6,789,133 bp[1]
End6,831,761 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TEKT1
Genomic location for TEKT1
Band11|11 B4Start72,235,548 bp[2]
End72,253,268 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • right uterine tube

  • olfactory zone of nasal mucosa

  • mucosa of paranasal sinus

  • left testis

  • right testis

  • sperm

  • epithelium of nasopharynx

  • testicle

  • nasal epithelium
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • utricle

  • olfactory epithelium

  • morula

  • vestibular sensory epithelium

  • Epithelium of choroid plexus

  • right lung lobe

  • choroid plexus of fourth ventricle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • microtubule cytoskeleton
  • cell projection
  • cilium
  • microtubule
  • cytoskeleton
  • nucleus
  • sperm flagellum
  • motile cilium
Biological process
  • flagellated sperm motility
  • cilium assembly
  • cilium movement involved in cell motility
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83659

21689

Ensembl

ENSG00000167858

ENSMUSG00000020799

UniProt

Q969V4

Q9DAJ2

RefSeq (mRNA)

NM_053285

NM_001282006
NM_001282007
NM_011569

RefSeq (protein)

NP_444515

NP_001268935
NP_001268936
NP_035699

Location (UCSC)Chr 17: 6.79 – 6.83 MbChr 11: 72.24 – 72.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tektin-1 is a protein that in humans is encoded by the TEKT1 gene.[5][6]

Function

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167858 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020799 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: tektin 1".
  6. ^ Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y (December 2001). "Cloning and characterization of a novel human TEKTIN1 gene". Int. J. Biochem. Cell Biol. 33 (12): 1172–82. doi:10.1016/S1357-2725(01)00089-9. PMID 11606253.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Newby PR, Pickles OJ, Mazumdar S, et al. (2010). "Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study". Eur. J. Hum. Genet. 18 (9): 1021–6. doi:10.1038/ejhg.2010.55. PMC 2987410. PMID 20442750.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Iguchi N, Tanaka H, Nakamura Y, et al. (2002). "Cloning and characterization of the human tektin-t gene". Mol. Hum. Reprod. 8 (6): 525–30. doi:10.1093/molehr/8.6.525. PMID 12029069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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