UFSP1

Protein-coding gene in the species Homo sapiens
UFSP1
Identifiers
AliasesUFSP1, UFSP, UFM1-specific peptidase 1 (inactive), UFM1 specific peptidase 1 (inactive)
External IDsOMIM: 611481; MGI: 1917490; HomoloGene: 80245; GeneCards: UFSP1; OMA:UFSP1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for UFSP1
Genomic location for UFSP1
Band7q22.1Start100,888,721 bp[1]
End100,889,715 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for UFSP1
Genomic location for UFSP1
Band5 G2|5 76.33 cMStart137,292,891 bp[2]
End137,293,927 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • muscle of thigh

  • stromal cell of endometrium

  • gastrocnemius muscle

  • mucosa of transverse colon

  • right adrenal cortex

  • granulocyte

  • left adrenal cortex

  • skeletal muscle tissue

  • right lobe of liver
Top expressed in
  • bone marrow

  • quadriceps femoris muscle

  • skeletal muscle tissue

  • proximal tubule

  • muscle of thigh

  • thoracic diaphragm

  • striatum of neuraxis

  • neural layer of retina

  • hypothalamus

  • muscle of arm
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • UFM1 hydrolase activity
  • cysteine-type peptidase activity
  • molecular function
Cellular component
  • extracellular exosome
Biological process
  • proteolysis
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

402682

70240

Ensembl

ENSG00000176125

ENSMUSG00000051502

UniProt

Q6NVU6

Q9CZP0

RefSeq (mRNA)

NM_001015072

NM_027356

RefSeq (protein)

NP_001015072

NP_081632

Location (UCSC)Chr 7: 100.89 – 100.89 MbChr 5: 137.29 – 137.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.[5]

Function

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009].[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176125 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051502 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. Public Domain This article incorporates text from this source, which is in the public domain.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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