Protein-coding gene in the species Homo sapiens
UFSP1 |
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Identifiers |
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Aliases | UFSP1, UFSP, UFM1-specific peptidase 1 (inactive), UFM1 specific peptidase 1 (inactive) |
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External IDs | OMIM: 611481; MGI: 1917490; HomoloGene: 80245; GeneCards: UFSP1; OMA:UFSP1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 7 (human)[1] |
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| Band | 7q22.1 | Start | 100,888,721 bp[1] |
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End | 100,889,715 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5 G2|5 76.33 cM | Start | 137,292,891 bp[2] |
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End | 137,293,927 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- muscle of thigh
- stromal cell of endometrium
- gastrocnemius muscle
- mucosa of transverse colon
- right adrenal cortex
- granulocyte
- left adrenal cortex
- skeletal muscle tissue
- right lobe of liver
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| Top expressed in | - bone marrow
- quadriceps femoris muscle
- skeletal muscle tissue
- proximal tubule
- muscle of thigh
- thoracic diaphragm
- striatum of neuraxis
- neural layer of retina
- hypothalamus
- muscle of arm
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - UFM1 hydrolase activity
- cysteine-type peptidase activity
- molecular function
| Cellular component | | Biological process | - proteolysis
- biological process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 7: 100.89 – 100.89 Mb | Chr 5: 137.29 – 137.29 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.[5]
Function
This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009].[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000176125 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051502 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.