USE1

Protein-coding gene in the species Homo sapiens
USE1
Identifiers
AliasesUSE1, P31, SLT1, D12, MDS032, unconventional SNARE in the ER 1
External IDsOMIM: 610675; MGI: 1914273; HomoloGene: 10214; GeneCards: USE1; OMA:USE1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for USE1
Genomic location for USE1
Band19p13.11Start17,215,346 bp[1]
End17,219,829 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for USE1
Genomic location for USE1
Band8|8 B3.3Start71,819,492 bp[2]
End71,822,376 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • anterior cingulate cortex

  • apex of heart

  • prefrontal cortex

  • amygdala

  • right frontal lobe

  • C1 segment

  • putamen

  • nucleus accumbens

  • Brodmann area 9
Top expressed in
  • superior surface of tongue

  • transitional epithelium of urinary bladder

  • supraoptic nucleus

  • vestibular sensory epithelium

  • interventricular septum

  • gallbladder

  • right lung lobe

  • skin of external ear

  • seminal vesicula

  • corneal stroma
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • lysosome
  • endoplasmic reticulum
  • membrane
  • endoplasmic reticulum membrane
Biological process
  • lysosomal transport
  • protein transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • protein catabolic process
  • vesicle-mediated transport
  • secretion by cell
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55850

67023

Ensembl

ENSG00000053501

ENSMUSG00000002395

UniProt

Q9NZ43

Q9CQ56

RefSeq (mRNA)

NM_018467

NM_001145780
NM_025917
NM_029768

RefSeq (protein)

NP_060937

NP_001139252
NP_080193

Location (UCSC)Chr 19: 17.22 – 17.22 MbChr 8: 71.82 – 71.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Uncharacterized hematopoietic stem/progenitor cells protein MDS032, also known as MDS032, is a protein which in humans is encoded by the MDS032 gene.[5][6]

Function

D12, the mouse homolog of MDS032, is a SNARE protein involved with the Golgi secretory apparatus and with endosome-lysosome transport.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000053501 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002395 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MDS032 uncharacterized hematopoietic stem/progenitor cells protein MDS032".
  6. ^ a b Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Hirose H, Arasaki K, Dohmae N, et al. (2005). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
  • Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Okumura AJ, Hatsuzawa K, Tamura T, et al. (2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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