USP34

Protein-coding gene in the species Homo sapiens
USP34
Identifiers
AliasesUSP34, ubiquitin specific peptidase 34
External IDsOMIM: 615295; MGI: 109473; HomoloGene: 40978; GeneCards: USP34; OMA:USP34 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for USP34
Genomic location for USP34
Band2p15Start61,187,463 bp[1]
End61,471,087 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for USP34
Genomic location for USP34
Band11 A3.2|11 14.29 cMStart23,256,895 bp[2]
End23,440,560 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nipple

  • renal medulla

  • cardia

  • pylorus

  • ventral tegmental area

  • trigeminal ganglion

  • superior surface of tongue

  • inferior ganglion of vagus nerve

  • external globus pallidus

  • sperm
Top expressed in
  • superior cervical ganglion

  • conjunctival fornix

  • barrel cortex

  • primary oocyte

  • genital tubercle

  • vas deferens

  • tail of embryo

  • CA3 field

  • spermatocyte

  • substantia nigra
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • cysteine-type endopeptidase activity
  • cysteine-type peptidase activity
  • peptidase activity
  • hydrolase activity
  • thiol-dependent deubiquitinase
Cellular component
  • cytosol
Biological process
  • proteolysis
  • ubiquitin-dependent protein catabolic process
  • positive regulation of canonical Wnt signaling pathway
  • protein K48-linked deubiquitination
  • Wnt signaling pathway
  • protein deubiquitination
  • regulation of protein stability
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9736

17847

Ensembl

ENSG00000115464

ENSMUSG00000056342

UniProt

Q70CQ2

Q6ZQ93

RefSeq (mRNA)

NM_014709

NM_001190401

RefSeq (protein)

NP_055524

NP_001177330

Location (UCSC)Chr 2: 61.19 – 61.47 MbChr 11: 23.26 – 23.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115464 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056342 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP34 ubiquitin specific peptidase 34".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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